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Magnesium in methanol(Mg / MeOH) system is an extremely versatile, efficient, economical and convenient reducing agent for various reactions useful for organic synthesis such as reductive cyclization, reductive elimination, reductive cleavage, reduction of a conjugated double bond, desulfonylation, and reduction of various functional groups. This comprehensive review is intended to highlight the use of Mg / MeOH in each of these organic transformations.