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I am please to once again be serving as the executive guest editor for Current Organic Chemistry's issue on molecular recognition. This volume will cover a wide range of topics related to molecular recognition ranging from small molecules to biomacromolecules. As usual I would like to thank all of the authors and the editorial staff for making this issue possible. The first review in this volume is a contribution from Ronald K. Castellano (University of Florida). Prof. Castellano has conducted an extensive and through study into the nature of the C-H---O interaction and its role in molecular recognition. Professor S. B Shuker (Georgia Institute of Technology) along with co-authors R.E. Brewster, K. L. Caran and J.S. Sasine reports on the use of a novel family of compounds, the peptidocalixarenes, in molecular recognition processes. A more biological look at molecular recognition if offered in the final review form Prof. John Barbaro (University of Florida) who has written a nice review on carbohydrate based molecular recognition.