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- Volume 32, Issue 2, 2025
Current Medicinal Chemistry - Volume 32, Issue 2, 2025
Volume 32, Issue 2, 2025
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The use of Isoflavones as Lung Cancer Chemoprevention Agents and their Implications in Treatment through Radio Sensitization
Authors: Efstratios Athanasiou, Savvas Papageorgiou, Marianna-Foteini Dafni, Ioannis Kelesis, Maria Vasileiou, Theodora Tatsiou, Vasiliki Kouveloglou, Panagiotis Kanatas, Ioannis Stouras, Athanasios Gatsis, Vasiliki-Taxiarchoula Agiassoti, Petros Nasimpian, Dimitrios Dafnoudis, Kyriaki Degaita, Georgios-Ioannis Verras, Athanasios Alexiou, Marios Papadakis and Mohammad Amjad KamalEpidemiological trends in cancer research show that lung cancer can affect up to 1 in 15 men and 1 in 17 women. With incidence rates as high as these and significant associated mortality and morbidity, it is no wonder that lung cancer is one of the main areas of research focused on cancer. Advances in targeted treatments and specialized irradiation protocols have allowed the treatment of more advanced cases. However, a Read More
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Carbon-based Nanomaterials in Photothermal Therapy Guided by Photoacoustic Imaging: State of Knowledge and Recent Advances
Authors: Yan Xing, Rui Jing, Jun Kang, Yuwen Li, Hui Zhang, Xiaoying Tang and Zhenqi JiangCarbon-based nanomaterials (CBNM) have been widely used in various fields due to their excellent physicochemical properties. In particular, in the area of tumor diagnosis and treatment, researchers have frequently reported them for their potential fluorescence, photoacoustic (PA), and ultrasound imaging performance, as well as their photothermal, photodynamic, sonodynamic, and other therapeutic properties. As the f Read More
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Exploring the Therapeutic Potential of Vesicular Nanocarrier Systems for Elimination of Skin Cancer
BackgroundSkin cancer, a common malignancy worldwide, has increased incidence and mortality. Thus, it is a public health issue and a significant illness burden, which increases treatment costs. Chemotherapy and surgery are used to treat skin cancer. However, conventional skin cancer treatments have several limitations, demanding the development of innovative, safe, and effective methods. To overcome these limitati Read More
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Smart Cancer Nanomedicine for Synergetic Therapy
Authors: Anwesha Kanungo, Chandana Mohanty and Sarbari AcharyaCancer is the second leading cause of death. Notwithstanding endeavors to comprehend tumor causes and therapeutic modalities, no noteworthy advancements in cancer therapy have been identified. Nanomedicine has drawn interest for its diagnostic potential because of its ability to deliver therapeutic agents specifically to tumors with little adverse effects. Nanomedicines have become prevalent in the treatment of cancer. Read More
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Advancements in Iron Oxide Nanoparticles for Multimodal Imaging and Tumor Theranostics
Authors: He Liu, Zhiming Zhen, Fengxi Chen, Jiafei Chen and Wei ChenThe emergence of nanomedicine offers renewed promise in the diagnosis and treatment of diseases. Due to their unique physical and chemical properties, iron oxide nanoparticles (IONPs) exhibit widespread application in the diagnosis and treatment of various ailments, particularly tumors. IONPs have magnetic resonance (MR) T1/T2 imaging capabilities due to their different sizes. In addition, IONPs also have biocatalytic acti Read More
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Regulating Triplet Excitons of Organic Luminophores for Promoted Bioimaging
Authors: Zhipeng Zhao, Rui Du, Xiaodi Feng, Zhengshuo Wang, Tianjie Wang, Zongzhao Xie, Hua Yuan, Yeqiang Tan and Hanlin OuAfterglow materials with organic room temperature phosphorescence (RTP) or thermally activated delayed fluorescence (TADF) exhibit significant potential in biological imaging due to their long lifetime. By utilizing time-resolved technology, interference from biological tissue fluorescence can be mitigated, enabling high signal-to- background ratio imaging. Despite the continued emergence of individual reports on RTP or TADF i Read More
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CDK4 as a Prognostic Marker of Hepatocellular Carcinoma and CDK4 Inhibitors as Potential Therapeutics
BackgroundThe proteins CDK4 and CDK6, which are extremely homologous, control cell cycle entry. For the treatment of breast tumors that include hormone receptors, CDK4 and CDK6 inhibitors have been authorized. The link between CDK4 and liver hepatocellular carcinoma (LIHC), however, has not yet been established.ObjectiveThe study aimed to explore the link between CDK4 and LIHC and the effect of CDK4 inhi Read More
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Determination of Inhibitory Effect of PKM2 Enzyme and Antitumoral Activity of Novel Coumarin-naphthoquinone Hybrids
Authors: Amanda de Andrade Borges, Gabriel Ouverney, Afonso Thales Sousa Arruda, Amanda Vieira Ribeiro, Ruan Carlos Busquet Ribeiro, Acácio Silva de Souza, Anna Carolina Carvalho da Fonseca, Lucas Nicolau de Queiroz, Elan Cardozo Paes de Almeida, Bruno Pontes, Vitor Won-Held Rabelo, Vitor Ferreira, Paula Alvarez Abreu, Fernando de Carvalho da Silva, Luana da Silva Magalhães Forezi and Bruno Kaufmann RobbsBackgroundOral squamous cell carcinoma (OSCC) represents the primary form of oral cancer, posing a significant global health threat. The existing chemotherapy options are accompanied by notable side effects impacting patient treatment adherence. Consequently, the exploration and development of novel substances with enhanced anticancer effects and fewer side effects have become pivotal in the realms of biologic Read More
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Amplifying Radiotherapy by Evoking Mitochondrial Oxidative Stress using a High-performance Aggregation-induced Emission Sonosensitizer
Authors: Xing Li, Yingshu Sun, Yilin Wang, Ye Zhou, Yixuan Bao, Zhuomiao Zhang, Shujing Liu, Huini Yang, Ruoyao Zhang, Peng Xia, Meiju Ji, Peng Hou and Chao ChenIntroductionDeveloping effective methods to enhance tumor radiosensitivity is crucial for improving the therapeutic efficacy of radiotherapy (RT). Due to its deep tissue penetration, excellent safety profile, and precise controllability, sonosensitizer-based sonodynamic therapy (SDT) has recently garnered significant attention as a promising combined approach with RT.MethodsHowever, the limited reactive oxygen species (ROS) g Read More
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Recent Advances in Drug Delivery Approaches for Rheumatoid Arthritis
Morbidity, disability, and healthcare expenses associated with rheumatoid arthritis (RA) impose a considerable health and economical burden on both patients and healthcare systems. This review aimed to examine the pathophysiological aspects of RA that may help design different types of drugs and drug delivery systems. These include monoclonal antibodies, immunoglobulins, tiny chemicals, and transgenes for gene thera Read More
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Volumes & issues
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Volume 32 (2025)
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Volume 31 (2024)
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Volume 30 (2023)
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Volume 29 (2022)
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Volume 28 (2021)
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Volume 27 (2020)
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Volume 26 (2019)
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Volume 25 (2018)
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Volume 24 (2017)
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Volume 23 (2016)
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Volume 22 (2015)
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Volume 21 (2014)
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Volume 20 (2013)
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Volume 19 (2012)
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Volume 18 (2011)
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Volume 17 (2010)
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Volume 16 (2009)
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Volume 15 (2008)
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Volume 14 (2007)
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Volume 13 (2006)
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Volume 12 (2005)
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Volume 11 (2004)
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Volume 10 (2003)
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Volume 9 (2002)
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Volume 8 (2001)
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Volume 7 (2000)
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