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Cardiovascular & Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents) - Online First
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Oxidative Stress in Cardiovascular Diseases: Mechanisms and Exploring Advanced Therapies
Authors: Dushyant, Balram, Gurvirender Singh, Nitish Kumar, Smita Narwal and Ashwani K. DhingraAvailable online: 26 February 2025More LessThe recognition of oxidative stress as a factor influencing the development and progression of cardiovascular diseases (CVDs) is growing. By producing such reactive oxygen species (ROS) in diverse areas within cells, including mitochondria and Nicotinamide Adenine Dinucleotide Phosphate Hydrogen (NADPH)-oxidases, they end up causing damage through the oxidation of lipids, proteins, and DNA. ROS indicates t Read More
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Emerging Biomarkers for Assessing Thrombotic Risk in Patients Receiving Direct Oral Anticoagulants (DOACs)
Authors: Ashmi Sabana M. and Alwin Simon M.Available online: 16 December 2024More LessDirect Oral Anticoagulants (DOACs) have transformed the management of thrombotic disorders, offering a more convenient and effective alternative to traditional vitamin K antagonists (VKAs). However, assessing thrombotic risk in patients treated with DOACS remains crucial due to the potential for recurrent events. Current clinical risk scores have limitations in predicting and monitoring venous thromboembolism (V Read More
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Novel Pathway and Recent Advances for Targeting Sickle Cell Anemia through Novel Drug Delivery System
Authors: Savita Chouhan, Ajazuddin and Parag JainAvailable online: 03 December 2024More LessRed blood cells with sickle cell anemia (SCA) have an irregular shape, and it is a genetic blood condition that can cause several problems and shorten life expectancy. Traditional treatments have focused on symptom management, but recent advancements in drug delivery systems offer promising pathways for targeted therapies. This abstract explores novel approaches to combat SCA through innovative drug delivery sy Read More
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Anti-thrombotic Mechanisms of Echinochrome A on Arterial Thrombosis in Rats: In-Silico, In-Vitro and In-Vivo Studies
Available online: 12 November 2024More LessBackground Arterial thrombosis is one of the most significant healthcare concerns in the world. Echinochrome A (Ech-A) is a natural quinone pigment isolated from sea urchins. It has a variety of medicinal values associated with its antioxidant, anticancer, antiviral, anti-diabetic, and cardio-protective activities. Objective The current study aims to investigate the effect and mechanism of Ech-A to inhibit thrombus form Read More
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Cardio-metabolic Disorders Affected by Genetic Polymorphisms Related to Premature Menopause
Authors: Mohammad Reza Mirinezhad, Hamideh Safarian Bana, Malihe Aghsizadeh, Mohammad Amin Mohammadi, Hamideh Ghazizadeh, Ali Ebrahimi Dabagh, Sayyedeh Helya Mir Nourbakhsh, Hassan Kiani Shahvandi, Alireza ghodsi, Mahdie Aghasizade, Faezeh Taghipour, Elahe Hasanzadeh, Nazanin Sheikh Andalibi, Hamed Khedmatgozar, Gordon A Ferns, Tayebeh Hamzehloei, Alireza Pasdar and Majid Ghayour-MobarhanAvailable online: 05 November 2024More LessBackground Premature menopause (PM) is defined as the end of ovulation before the age of 40 years, a condition commonly referred to as primary ovarian insufficiency. It has been shown there is an association between early menopause and a high risk of cardiovascular disease. Aim This study aimed to evaluate the effect of genetic polymorphisms related to premature menopause on cardio-metabolic disorders Objec Read More
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The Effect of CD31 on Coronary Collateral Development
Available online: 28 August 2024More LessBackground Coronary collaterals are the feeding bridges between the main epicardial arteries, and research has shown that this collateral development plays a crucial role in myocardial performance, especially in patients with coronary artery disease. However, the evolution of these collaterals has not been fully explained. Objective In this study, we aimed to reveal the effect of CD31 on coronary collateral developme Read More
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