Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Cardiovascular & Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents)
  4. Volume 22, Issue 4
  5. Article
Volume 22, Issue 4
  • ISSN: 1871-5257
  • E-ISSN: 1875-6182

Abstract

Background

Numerous complications, such as postoperative arrhythmia and stroke, have been observed following coronary artery bypass graft (CABG) surgery.

Aims

This study sought to examine the impact of aging on the incidence of post-coronary artery shunt complications.

Objectives

Aging is a physiological process experienced by every living cell, beginning early in development. Age plays a crucial role in determining postoperative complications, including those related to CABG.

Materials and Methods

A retrospective analysis was conducted on 290 patients who underwent CABG at the Mordovian Republic Hospital between 2017 and 2021. The sample was divided into two age-based groups: the first group comprised 126 patients (mean age range: 55.21-60.00), and the second group included 163 patients (mean age range: 66.11-80.00). Statistical analyses employed in this study encompassed descriptive statistics, Chi-square test, T-test, one-way ANOVA test, ROC analysis, and Pearson correlation using Statistica 12 software.

Results

Elderly patients in the second group demonstrated a higher incidence of post-CABG arrhythmia ( < 0.012528). Moreover, the second group experienced markedly longer ICU and total hospitalization days following CABG, with p-values of less than 0.000000 and 0.000072, respectively. Notably, elderly individuals in the second group faced an increased risk of developing psychosis after CABG surgery ( < 0.007379). Furthermore, psychosis was found to be significantly associated with longer ICU hospitalization ( < 0.000140). Postoperative stroke occurred more frequently among the elderly (second group) with a p-value of less than 0.037736. Consequently, postoperative stroke was associated with extended ICU hospitalization ( < 0.000747). The usage of internal thoracic arteries (ITAs) was lower among the elderly (second group), with a p-value of less than 0.016145. Regarding correlations, a direct association was observed between age and ICU days, total hospitalization days, and the number of complications, with correlation coefficients (r) of 0.189046, 0.141415, and 0.138565, respectively.

Conclusion

Elderly individuals in the second group who undergo CABG face a greater risk of developing psychosis, arrhythmia, prolonged total and ICU hospitalization, and stroke. The presence of arrhythmia, which is commonly observed in patients aged 63 years and older, significantly affects total hospitalization days. The number of complications is influenced by age, cardiopulmonary bypass (CPB) time, aortic cross-clamp time, ICU hospitalization, and total hospitalization duration.

© 2024 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/chamc/10.2174/0118715257265595231128070227
2024-12-01
2024-11-22

  • From This Site

    /content/journals/chamc/10.2174/0118715257265595231128070227
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. GaudinoM. BenedettoU. FremesS. Biondi-ZoccaiG. SedrakyanA. PuskasJ.D. AngeliniG.D. BuxtonB. FratiG. HareD.L. HaywardP. NassoG. MoatN. PericM. YooK.J. SpezialeG. GirardiL.N. TaggartD.P. Radial-Artery or Saphenous-Vein Grafts in Coronary-Artery Bypass Surgery.N. Engl. J. Med.2018378222069207710.1056/NEJMoa1716026 29708851
     [Google Scholar]
  2. LeyviG. ForestS.J. SrinivasV.S. GreenbergM. WangN. MaisA. SnyderM.J. DeRoseJ.J. Jr Robotic coronary artery bypass grafting decreases 30-day complication rate, length of stay, and acute care facility discharge rate compared with conventional surgery.Innovations (Phila.)20149536136710.1097/imi.0000000000000095 25238421
     [Google Scholar]
  3. PooriaA. PouryaA. GheiniA. Postoperative complications associated with coronary artery bypass graft surgery and their therapeutic interventions.Future Cardiol.202016548149610.2217/fca‑2019‑0049 32495650
     [Google Scholar]
  4. PalmeriniT. SaviniC. Di EusanioM. Risks of Stroke After Coronary Artery Bypass Graft – Recent Insights and Perspectives.Interv. Cardiol.201192778310.15420/icr.2011.9.2.77 29588782
     [Google Scholar]
  5. SabikJ.F.III BlackstoneE.H. GillinovA.M. SmediraN.G. LytleB.W. Occurrence and risk factors for reintervention after coronary artery bypass grafting.Circulation20061141Suppl.I454I46010.1161/CIRCULATIONAHA.105.001149 16820618
     [Google Scholar]
  6. MontriefT. KoyfmanA. LongB. Coronary artery bypass graft surgery complications: A review for emergency clinicians.Am. J. Emerg. Med.201836122289229710.1016/j.ajem.2018.09.014 30217621
     [Google Scholar]
  7. ZhangR.J.Z. YuX.Y. WangJ. LvJ. YuM.H. WangL. LiuZ.G. Comparison of in-hospital outcomes after coronary artery bypass graft surgery in elders and younger patients: A multicenter retrospective study.J. Cardiothorac. Surg.20231815310.1186/s13019‑023‑02163‑y 36726146
     [Google Scholar]
  8. HokkanenM. HuhtalaH. LaurikkaJ. JärvinenO. The effect of postoperative complications on health-related quality of life and survival 12 years after coronary artery bypass grafting – a prospective cohort study.J. Cardiothorac. Surg.202116117310.1186/s13019‑021‑01527‑6 34127023
     [Google Scholar]
  9. AikawaP. CintraA.R.S. LeiteC.A. MarquesR.H. SilvaC.T.M. AfonsoM.S. PaulitschF.S. OssE.A. Impact of coronary artery bypass grafting in elderly patients.Rev. Bras. Cir. Cardiovasc.2013281222810.5935/1678‑9741.20130005 23739929
     [Google Scholar]
  10. MarzoogB.A. VlasovaT.I. Myocardiocyte autophagy in the context of myocardiocytes regeneration: A potential novel therapeutic strategy.Egypt. J. Med. Hum. Genet.20222314110.1186/s43042‑022‑00250‑8
     [Google Scholar]
  11. MarzoogB.A. RomanovnaA.D. Early Prognostic Instrumental & Laboratory Markers in Post-MI.MedRxiv202310.1101/2023.05.13.23289438
     [Google Scholar]
  12. MarzoogB.A. AlexandrovichK.O. NikolaevichT.M. VladimirovichK.S. Post-Coronary Artery Bypass Graft Complications; Potential Causes and Risk Factors.MedRxiv2023
     [Google Scholar]
  13. BrownP.P. KugelmassA.D. CohenD.J. ReynoldsM.R. CullerS.D. DeeA.D. SimonA.W. The frequency and cost of complications associated with coronary artery bypass grafting surgery: Results from the United States Medicare program.Ann. Thorac. Surg.20088561980198610.1016/j.athoracsur.2008.01.053 18498806
     [Google Scholar]
  14. RoachG.W. KanchugerM. ManganoC.M. NewmanM. NussmeierN. WolmanR. AggarwalA. MarschallK. GrahamS.H. LeyC. OzanneG. ManganoD.T. HerskowitzA. KatsevaV. SearsR. Adverse cerebral outcomes after coronary bypass surgery.N. Engl. J. Med.1996335251857186410.1056/NEJM199612193352501 8948560
     [Google Scholar]
  15. PalmeriniT. Biondi-ZoccaiG. ReggianiL.B. SangiorgiD. AlessiL. De ServiS. BranziA. StoneG.W. Risk of stroke with coronary artery bypass graft surgery compared with percutaneous coronary intervention.J. Am. Coll. Cardiol.201260979880510.1016/j.jacc.2011.10.912 22917004
     [Google Scholar]
  16. van der LindenJ. HadjinikolaouL. BergmanP. LindblomD. Postoperative stroke in cardiac surgery is related to the location and extent of atherosclerotic disease in the ascending aorta.J. Am. Coll. Cardiol.200138113113510.1016/S0735‑1097(01)01328‑6 11451262
     [Google Scholar]
  17. NaylorA.R. MehtaZ. RothwellP.M. BellP.R.F. Carotid artery disease and stroke during coronary artery bypass: A critical review of the literature.Eur. J. Vasc. Endovasc. Surg.200223428329410.1053/ejvs.2002.1609 11991687
     [Google Scholar]
  18. CharlesworthD.C. LikoskyD.S. MarrinC.A.S. MaloneyC.T. QuintonH.B. MortonJ.R. LeavittB.J. CloughR.A. O’ConnorG.T. Development and validation of a prediction model for strokes after coronary artery bypass grafting.Ann. Thorac. Surg.200376243644310.1016/S0003‑4975(03)00528‑9 12902080
     [Google Scholar]
  19. HorneroF. MartínE. RodríguezR. CastellàM. PorrasC. RomeroB. MarotoL. Pérez De La SotaE. A multicentre Spanish study for multivariate prediction of perioperative in-hospital cerebrovascular accident after coronary bypass surgery: The PACK2 score.Interact. Cardiovasc. Thorac. Surg.201317235335810.1093/icvts/ivt102 23628652
     [Google Scholar]
  20. MathisenL. AndersenM.H. HolP.K. TennøeB. LundC. RussellD. LundbladR. HalvorsenS. WahlA.K. HanestadB.R. FosseE. Preoperative cerebral ischemic lesions predict physical health status after on-pump coronary artery bypass surgery.J. Thorac. Cardiovasc. Surg.200513061691169710.1016/j.jtcvs.2005.08.008 16308017
     [Google Scholar]
  21. KhanM.F. HerleA. Reza MovahedM. Risk Factors for Post-Coronary Artery Bypass Grafting (CABG) Atrial Fibrillation and the Role of Aspirin and Beta Blockers in its Prevention.J. Atr. Fibrillation20135580010.4022/JAFIB.800 28496818
     [Google Scholar]
  22. KarkoutiK. CohenM.M. McCluskeyS.A. SherG.D. A multivariable model for predicting the need for blood transfusion in patients undergoing first-time elective coronary bypass graft surgery.Transfusion200141101193120310.1046/j.1537‑2995.2001.41101193.x 11606816
     [Google Scholar]
  23. SellmanM. IntontiM.A. IvertT. Reoperations for bleeding after coronary artery bypass procedures during 25 years.Eur. J. Cardiothorac. Surg.199711352152710.1016/S1010‑7940(96)01111‑6 9105818
     [Google Scholar]
  24. HorwichP. ButhK.J. LégaréJ.F. New onset postoperative atrial fibrillation is associated with a long-term risk for stroke and death following cardiac surgery.J. Card. Surg.201328181310.1111/jocs.12033 23186205
     [Google Scholar]
  25. AmarD. ShiW. HogueC.W.Jr ZhangH. PassmanR.S. ThomasB. BachP.B. DamianoR. ThalerH.T. Clinical prediction rule for atrial fibrillation after coronary artery bypass grafting.J. Am. Coll. Cardiol.20044461248125310.1016/j.jacc.2004.05.078 15364327
     [Google Scholar]
  26. VillarealR.P. HariharanR. LiuB.C. KarB. LeeV.V. ElaydaM. LopezJ.A. RasekhA. WilsonJ.M. MassumiA. Postoperative atrial fibrillation and mortality after coronary artery bypass surgery.J. Am. Coll. Cardiol.200443574274810.1016/j.jacc.2003.11.023 14998610
     [Google Scholar]
  27. McKhannG.M. GregaM.A. BorowiczL.M.Jr BaumgartnerW.A. SelnesO.A. Stroke and encephalopathy after cardiac surgery: An update.Stroke200637256257110.1161/01.STR.0000199032.78782.6c 16373636
     [Google Scholar]
  28. CarnesC.A. ChungM.K. NakayamaT. NakayamaH. BaligaR.S. PiaoS. KanderianA. PaviaS. HamlinR.L. McCarthyP.M. BauerJ.A. Van WagonerD.R. Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation.Circ. Res.2001896E32E3810.1161/hh1801.097644 11557745
     [Google Scholar]
  29. De VecchiE. PalaM.G. Di CredicoG. AgapeV. PaoliniG. BoniniP.A. GrossiA. ParoniR. Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery.Heart199879324224710.1136/hrt.79.3.242 9602656
     [Google Scholar]
  30. DimmerC. TavernierR. GjorgovN. Van NootenG. ClementD.L. JordaensL. Variations of autonomic tone preceding onset of atrial fibrillation after coronary artery bypass grafting.Am. J. Cardiol.1998821222510.1016/S0002‑9149(98)00231‑8 9671003
     [Google Scholar]
  31. KalmanJ.M. MunawarM. HowesL.G. LouisW.J. BuxtonB.F. GutteridgeG. TonkinA.M. Atrial fibrillation after coronary artery bypass grafting is associated with sympathetic activation.Ann. Thorac. Surg.19956061709171510.1016/0003‑4975(95)00718‑0 8787468
     [Google Scholar]
  32. BudeusM. HennersdorfM. RöhlenS. SchnitzlerS. FelixO. ReimertK. FeindtP. GamsE. WienekeH. SackS. ErbelR. PeringsC. Prediction of atrial fibrillation after coronary artery bypass grafting: The role of chemoreflexsensitivity and P wave signal averaged ECG.Int. J. Cardiol.20061061677410.1016/j.ijcard.2004.12.062 16321669
     [Google Scholar]
  33. TsikourisJ.P. KlugerJ. SongJ. WhiteC.M. Changes in P-wave dispersion and P-wave duration after open heart surgery are associated with the peak incidence of atrial fibrillation.Heart Lung200130646647110.1067/mhl.2001.118363 11723451
     [Google Scholar]
  34. EngelmannM.D.M. SvendsenJ.H. Inflammation in the genesis and perpetuation of atrial fibrillation.Eur. Heart J.200526202083209210.1093/eurheartj/ehi350 15975993
     [Google Scholar]
  35. BruinsP. VelthuisH. YazdanbakhshA.P. JansenP.G.M. van HardeveltF.W.J. de BeaumontE.M.F.H. WildevuurC.R.H. EijsmanL. TrouwborstA. HackC.E. Activation of the complement system during and after cardiopulmonary bypass surgery: Postsurgery activation involves C-reactive protein and is associated with postoperative arrhythmia.Circulation199796103542354810.1161/01.CIR.96.10.3542 9396453
     [Google Scholar]
  36. AbdelhadiR.H. GurmH.S. Van WagonerD.R. ChungM.K. Relation of an exaggerated rise in white blood cells after coronary bypass or cardiac valve surgery to development of atrial fibrillation postoperatively.Am. J. Cardiol.20049391176117810.1016/j.amjcard.2004.01.053 15110218
     [Google Scholar]
  37. TomicV. RusswurmS. MöllerE. ClausR.A. BlaessM. BrunkhorstF. BruegelM. BodeK. BloosF. WippermannJ. WahlersT. DeignerH.P. ThieryJ. ReinhartK. BauerM. Transcriptomic and proteomic patterns of systemic inflammation in on-pump and off-pump coronary artery bypass grafting.Circulation2005112192912292010.1161/CIRCULATIONAHA.104.531152 16275880
     [Google Scholar]
  38. PuskasJ.D. EdwardsF.H. PappasP.A. O’BrienS. PetersonE.D. KilgoP. FergusonT.B.Jr Off-pump techniques benefit men and women and narrow the disparity in mortality after coronary bypass grafting.Ann. Thorac. Surg.20078451447145610.1016/j.athoracsur.2007.06.104 17954045
     [Google Scholar]
  39. AfilaloJ. RastiM. OhayonS.M. ShimonyA. EisenbergM.J. Off-pump vs. on-pump coronary artery bypass surgery: An updated meta-analysis and meta-regression of randomized trials.Eur. Heart J.201233101257126710.1093/eurheartj/ehr307 21987177
     [Google Scholar]
  40. MøllerC.H. PenningaL. WetterslevJ. SteinbrüchelD.A. GluudC. Off-pump versus on-pump coronary artery bypass grafting for ischaemic heart disease.Cochrane Libr.20123CD00722410.1002/14651858.CD007224.pub2 22419321
     [Google Scholar]
  41. MarzoogB.A. AlexandrovichK.O. NikolaevichT.M. VladimirovichK.S. Post-Coronary Artery Bypass Graft Complications; Potential Causes and Risk Factors.Emir. Med. J.2023410.2174/0250688204666230410084313
     [Google Scholar]
/content/journals/chamc/10.2174/0118715257265595231128070227
Loading
Incidence Rate of Post Coronary Artery Shunt Complications; Age Dependent!
Cardiovasc. Hematol. Agents Med. Chem. 22, 466 (2024); https://doi.org/10.2174/0118715257265595231128070227
/content/journals/chamc/10.2174/0118715257265595231128070227
/content/journals/chamc/10.2174/0118715257265595231128070227
Loading

Data & Media loading...


  • Article Type:     Research Article
Keyword(s): angioplasty; CABG; CVD & CVS; myocardial infarction; progressive angina; Surgery

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test