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Volume 20, Issue 1
  • ISSN: 1574-8855
  • E-ISSN: 2212-3903

Abstract

Background

Epilepsy is the most common neurological disorder, characterized by abnormal, unpredictable, and recurrent seizures. In the alternative medicine system, Artemisia vulgaris has been used to treat epileptic symptoms since its inception. However, scientific evidence concerning its effect on the treatment of epileptic seizures is not available.

Objectives

The objective of the study is to evaluate the anti-convulsant potential of Artemisia vulgaris in zebrafish experimental models.

Methods

Zebrafish larvae and adult zebrafish were used as experimental models. Briefly, larvae and adult zebrafish were exposed to 0.5% of the test medicine Artemisia vulgaris mother tincture (ϕ) and its potencies (6 CH, 30 CH), and valproic acid for 1 hour. After 1 hour of exposure, they were exposed to pentylenetetrazole to record different seizure scores from 1 to 5 using ANY maze video tracking software.

Results

Artemisia vulgaris 30CH in zebrafish larvae and Artemisia vulgaris 6 CH and 30 CH in adult zebrafish delayed the latency score from score 1 to score 5 and were found effective against PTZ-induced locomotor activity and seizure duration and intensity.

Conclusion

In conclusion, Artemisia vulgaris (6 CH and 30 CH) has the potential to be a novel treatment for symptomatic epileptic seizures and could be a potential alternative drug candidate for symptomatic treatment of epilepsy.

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2024-01-08
2024-11-26

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/content/journals/cdth/10.2174/0115748855268042231130041958
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Pharmacological Investigation of Anticonvulsant Effect of Artemisia Vulgaris on Pentylenetetrazole-Induced Epileptic Seizures in Zebrafish Experimental Model
Curr Drug Ther 20, 95 (2025); https://doi.org/10.2174/0115748855268042231130041958
/content/journals/cdth/10.2174/0115748855268042231130041958
/content/journals/cdth/10.2174/0115748855268042231130041958
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  • Article Type:     Research Article
Keyword(s): alternative therapy; anti-convulsant; Convulsion; danio rerio; epilepsy; larvae

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