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Volume 20, Issue 1
  • ISSN: 1574-8855
  • E-ISSN: 2212-3903
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Abstract

Osteoporosis (OP) remains a significant global health challenge, marked by high prevalence and considerable economic burden, yet effective therapeutic options remain limited. Central to the pathogenesis of OP is mitochondrial dysfunction, which adversely impacts bone formation and resorption. This review provides an in-depth analysis of the complex relationship between mitochondrial function and OP, elucidating critical molecular mechanisms and identifying promising therapeutic agents. Among these, zoledronic acid and resveratrol stand out, demonstrating significant efficacy in enhancing mitochondrial functions and enhancing bone density in both preclinical models and clinical trials. Moreover, innovative drug delivery systems, such as mitochondrial-targeted nanodelivery systems and localized delivery methods, have been developed to ensure precise targeting and reduce systemic side effects, thereby enhancing bioavailability and therapeutic outcomes. By delving into these advancements, this review seeks to facilitate the translation of mitochondrial-targeted therapies from preclinical research to clinical application, ultimately advancing OP management and improving patient outcomes.

© 2025 Bentham Science Publishers
© 2025 The Author(s). Published by Bentham Science Publishers. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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/content/journals/cdth/10.2174/0115748855342971240816120237
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Targeted Drug Delivery for Precision Mitochondrial Therapy in Osteoporosis: Therapeutic Strategies and Advances
Curr Drug Ther 20, 76 (2025); https://doi.org/10.2174/0115748855342971240816120237
/content/journals/cdth/10.2174/0115748855342971240816120237
/content/journals/cdth/10.2174/0115748855342971240816120237
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  • Article Type:     Review Article
Keyword(s): drug delivery; hydrogels; mitochondrial dysfunction; mitochondrial-targeted drugs; nanoparticles; Osteoporosis; scaffolds

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