Current Cancer Therapy Reviews - Volume 21, Issue 1, 2025

Breast cancer poses a significant global health challenge, and if current trends persist, the burden of breast cancer is projected to escalate, yielding over 3 million new cases and 1 million fatalities annually by the year 2040. Breast cancer is a highly heterogeneous disease, presenting a spectrum of subtypes, each characterized by unique clinical behaviors and responses to treatments. Understanding these breast cancer subtypes Read More

Colorectal cancer (CRC) is a commonly diagnosed cancer responsible for numerous deaths worldwide. In recent decades, technological advances implicated in considering the molecular pathways underlying CRC pathogenesis. Several investigations have identified various mechanisms involved in CRC and have paved the way for new therapeutics and early diagnosis. Gut microbiome play a crucial role in intestinal inflammation a Read More

Retinoblastoma is the most common pediatric ocular cancer. This cancer occurs due to malignancy in retinoblast cells, which are precursors of photoreceptors, horizontal cells, amacrine cells, muller cells, and retinal progenitor cells in the retina of the eye. Genetic correlation has been observed in most cases of retinoblastoma. It is caused due to the suppression or mutation of the retinoblastoma 1 gene (RB1 gene), whi Read More

Breast cancer is an aggressive disease with a significant morbidity and death rate among women worldwide. Despite the progress of diagnostic and therapy options for breast cancer in recent years, the prognosis and survival rates of breast cancer patients remain unsatisfactory. The aberrant growth and spread of tumor cells are the leading cause of death in these patients. More profound knowledge of molecular biology under Read More

Leukaemia, lymphoma, and myeloma are among the serious and frequently fatal conditions that impact thousands of people each year. Genetics, environmental factors, and medical problems can all affect the risk of developing blood cancer, however, the precise causes are still not entirely known. Fatigue, unexpected weight loss, and frequent infections are examples of common blood cancer symptoms. In the course of the Read More

The second most prevalent cause of fatalities globally is malignant tumors. The avoidance and therapy of cancer proliferation still have many prospects for betterment despite enormous advancements. Chemotherapy can occasionally have a lot of unfavorable adverse reactions. Novel agents from botanicals, especially the use of cancer therapeutic ingredients, may decrease negative consequences. There are currently Read More

Cancer is one of the main causes of mortality that affects a large propotion of population worldwide each year. Traditional and synthetic medications are less successful in cancer treatment. The deleterious effects of synthetic compounds divert our attention toward the utilization of naturally derived compounds in current clinical research. The impact of biodiversity on population development and livelihood represent Read More

BackgroundChemotherapy resistance often occurs in the conventional treatment with AML and results in poor cure rates. CKI was found to have a good therapeutic effect when it was combined with other chemotherapy drugs in the clinical treatment of AML. However, the underlying mechanism is unclear. Therefore, this study aims to preliminarily describe the pharmacological activity and mechanism of CKI through c Read More

IntroductionCyclin-dependent kinases (CDKs) are serine/threonine kinase proteins that regulate the cell cycle through phosphorylation and dephosphorylation. These proteins are a main target in cancer therapy. This study investigated the effect of omeprazole on CDK2, CDK4, and CDK6 through simulation studies.MethodsTo investigate the interaction between omeprazole and CDK2, 4, and 6, the three-dimensional struct Read More

PurposeVulval Hidradenoma papilliferum is a rare benign tumor originating from apocrine sweat glands. They present as a solid solitary nodule of 1-2 cm on the inner margin of labia majora. Since they are not commonly encountered, their diagnosis is usually difficult and puzzles with other conditions such as benign and malignant lesions of the skin, vulva, and perineum. The present case report highlights one such case of v Read More