Combinatorial Chemistry & High Throughput Screening - Volume 28, Issue 3, 2025

Brain-related disorders include neuroinflammation, neurodegenerative disorders, and demyelination, which ultimately affect the quality of life of patients. Currently, brain-related disorders represent the most challenging health problem worldwide due to complex pathogenesis and limited availability of drugs for their management. Further, the available pharmacotherapy accompanies serious side effects, therefore, much a Read More

Amines are important and valuable compounds widely used in the chemical industry to produce various products such as dyes, detergents, solvents, additives, pharmaceutical products, and anti-foam agents. A property that distinguishes primary amines from other compounds is their straightforward functionalization. Therefore, the synthesis of different amine compounds has been considered by many researchers in r Read More

Point of Care Diagnostics (POCD) is quintessential in hospitals and the healthcare sector as the secants uplift the quality of medical care and the life of a patient by facilitating quick identification of the underlying pathological condition. Nanotechnology can provide opportunities and has potential in the development of new-age sensing/diagnostic tools. Owing to extraordinary features (e.g., higher density, effective catalysis, good c Read More

PurposeTo systematically evaluate the relationship between cutaneous immune-related adverse events (cirAEs) and the efficacy of PD-1/PD-L1 in the treatment of non-small cell lung cancer (NSCLC) and to provide an evidence-based reference for the clinical application of PD-1/PD-L1 and safety evaluation.MethodsElectronic databases (PubMed, Embase, Medline, Web of Science, and the Cochrane Library) were screened s Read More

BackgroundPhage therapy could play an important role in the bacterial pneumonia. However, the exact role of phage therapy in bacterial pneumonia is unclear to date.AimThe current study aims to find out the role of phage therapy in preclinical models of bacterial pneumonia.MethodsThe studies were searched in databases with proper MeSH terms along with Boolean operators and selected based Read More

BackgroundAs a Chinese medicinal formula, the Jianshen Lishui prescription has been clinically proven to be effective in treating intracerebral hemorrhage (ICH). Yet, the mechanisms involved are unknown.MethodsNetwork pharmacology analysis: It involved the screening of active components in the Jianshen Lishui prescription, identification of potential targets for these components, and the screening of ICH-relate Read More

PurposeAtherosclerosis is the most common and significant form of arterial disease, characterized primarily by lipid accumulation and inflammatory cell infiltration as its main pathological basis. This study aims to investigate the molecular mechanisms and associated pathways by which iron accumulation may be involved in lipid metabolism abnormalities in atherosclerotic mice.MethodsRelying on ApoE-/- mouse bo Read More

BackgroundChronic bronchitis is a type of common chronic inflammatory respiratory disease, which is mainly characterized by chronic cough and expectoration. Clinical practice and experimental research have shown that the modified tonifying spleen-lung method has significant preventive and therapeutic effects on chronic lung diseases, but the mechanism of TSLR in the treatment of chronic bronchitis are not yet clear.Obj Read More

BackgroundLung adenocarcinoma (LUAD) is a common malignant tumor with no obvious clinical symptoms in its early stages. Patients can be divided into radiotherapy-sensitive groups (RS) and radiotherapy-resistant groups (RR) due to their varying conditions. The therapeutic effect of radiotherapy is quite different between the two groups. Therefore, this paper explores the role of radiation-related lung function genes i Read More

BackgroundEsophageal cancer (EC) is one of the deadliest malignancies worldwide. Gynostemma pentaphyllum Thunb. Makino (GpM) has been used in traditional Chinese medicine as a treatment for tumors and hyperlipidemia. Nevertheless, the active components and underlying mechanisms of anti-EC effects of GpM remain elusive.ObjectiveThis study aims to determine the major active ingredients of GpM in the t Read More

IntroductionResearch regarding post-operative brain protection after deep hypothermic circulatory arrest (DHCA) has gained attracted significant attention. We previously demonstrated that hydrogen can significantly reverse DHCA-induced brain damage.MethodsIn the current research, we have established the DHCA model successfully using a modified four-vessel occlusion method and injected miR-29s compounds into the Read More

IntroductionTraditional Chinese medicine (TCM) can modulate the immune function of tumor patients in various ways. Zuojin Wan (ZJW, a 6:1 ratio of Huang Lian and Wu Zhu Yu) can modulate the microenvironment of ulcerative colitis, but its role in regulating the colorectal cancer (CRC) microenvironment remains unclear. Exploring the role of ZJW in CRC immunomodulation may improve the antitumor effect of existing i Read More

AimsThe aim of this study is to explore the anti-depressant mechanism of Chaihu-Shugan San based on serum medicinal chemistry and network pharmacology methods.BackgroundDepression lacks effective treatments, with current anti-depressants ineffective in 40% of patients. Chaihu-Shugan San (CHSGS) is a well-known traditional Chinese medicine compound to treat depression. However, the chemical components a Read More