Combinatorial Chemistry & High Throughput Screening - Volume 28, Issue 2, 2025

Hepatocellular carcinoma is the sixth most common tumor and the third leading cause of cancer death worldwide. It ranks fourth in the spectrum of malignant tumor incidence and second in the order of death from major malignant tumors in China. Hepatocellular carcinoma is a complex ecosystem containing non-tumor cells (mainly immune-related cells), and its immunotherapy can stimulate the recognition of specific tu Read More

Recent advances in science and technology have led to revolutions in many scientific and industrial fields. The term lab on a chip, or in other words, performing a variety of complex analyses in just a short time and a minimal space, is a term that has become very common in recent years, and what used to be a dream has now come to life in practice. In this paper, we tried to investigate a specific type of lab technology on a chi Read More

Organic solvents are hazardous and should be replaced with less harmful alternatives. When developing a new formulation for a medicine with low aqueous solubility, improving its solubility might be a significant difficulty. According to the mixed solvency concept, a novel concept of solubilization, the solubility of poorly soluble drugs can be increased by dissolving them in a concentrated solution comprising various su Read More

BackgroundBenzodiazepines (BZD) and Z-drugs are often prescribed for alleviating such symptoms and treating maternal psychiatric disorders and epilepsy. However, their use is limited due to the apprehensions and risks related to poor maternal and neonatal outcomes.ObjectiveThis meta-analysis evaluated the rationality and efficacy of using Benzodiazepines and Z-drugs for managing anxiety and depression in pregnant w Read More

BackgroundMetabolic syndrome (MetS) is a cluster of cardiovascular risk factors, including abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. Gastric cancer (GC) is a common malignancy with significant mortality rates. The relationship between MetS and GC risk remains controversial. This systematic review and meta-analysis aimed to evaluate the correlation between MetS and GC.MethodsCase-control s Read More

AimThe objective of this study is to explore the impact and underlying mechanism of S. baicalensis Georgi stem and leaf flavonoids (SSFs) on cognitive impairment caused by intracerebroventricular injection of okadaic acid (OA) in rats.MethodsAn experimental model of Alzheimer's disease (AD) was induced in rats by intracerebroventricular injection of OA, resulting in memory impairment. The Morris water maze test was e Read More

ObjectiveMesangial proliferative glomerulonephritis (MsPGN) is an important cause of chronic kidney disease. Abnormal proliferation of mesangial cells and immune-inflammatory response are its important pathological manifestations. Currently, there is no ideal treatment for this disease. Fufang Banbianlian Injection (FBI) has anti-inflammatory, antioxidant, and immune-enhancing effects, and is mostly used for the treatm Read More

BackgroundLuteolin, a flavonoid found in various medicinal plants, has shown promising antioxidant, anti-inflammatory, and anti-aging properties. The cartilaginous endplate (CEP) represents a crucial constituent of the intervertebral disc (IVD), assuming a pivotal responsibility in upholding both the structural and functional stability of the IVD.ObjectiveExploring the precise mechanism underlying the protective effects of luteolin a Read More

BackgroundLupus nephritis is an autoimmune disease, and its pathogenesis involves inflammation and autophagy disorders. Studies have demonstrated that Astragalus membranaceus can effectively suppress the progression of LN, but the underlying therapeutic target is still unclear.ObjectionThis study aimed to investigate the therapeutic target whereby AM ameliorates LN.MethodsWe downloaded AM and LN Read More

ObjectiveLymphoma is the most common malignancy of the haematological system. Jeduxiaoliu formula (JDXLF) exerts good therapeutic effects against lymphoma, however, the mechanisms underlying these effects remain unclear. Therefore, this study aimed to investigate the mechanism of action of JDXLF.MethodsRNA-Seq was performed to examine the molecular mechanisms underlying the therapeutic effects of JDXLF a Read More

BackgroundThe Danggui–Kushen herb pair (DKHP) is a classic prescription that has long been used in combination with chemotherapeutic drugs to improve the immune status of patients with breast cancer (BC), however, the active components and the underlying pharmacological mechanisms remain unclear. Therefore, this study aimed to elucidate the possible mechanism of action of DKHP against BC-based comprehensive str Read More

BackgroundJinwei decoction can enhance the anti-inflammatory effect of glucocorticoid (GC) on chronic obstructive pulmonary disease (COPD) by restoring the activity of human histone deacetylase-2 (HDAC2). However the upstream mechanism of Jinwei decoction on HDAC2 expression is not clear.ObjectiveTo explore the target of Jinwei decoction to enhance the anti-inflammatory effect of GC on COPD through microRNA155-5 Read More