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Volume 28, Issue 3
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

Background

Phage therapy could play an important role in the bacterial pneumonia. However, the exact role of phage therapy in bacterial pneumonia is unclear to date.

Aim

The current study aims to find out the role of phage therapy in preclinical models of bacterial pneumonia.

Methods

The studies were searched in databases with proper MeSH terms along with Boolean operators and selected based on eligibility criteria as per the PRISMA guidelines. The Odd Ratio (OR) was calculated with a 95% confidence interval and the heterogeneity was also calculated. The funnel plot was used to conduct a qualitative examination of publication bias.

Results

The OR was observed to be 0.11 (0.04, 0.27)] after 24 hrs, 0.11 [0.03, 0.34] after 7 days and 0.04 [0.01, 0.15] after 10 days that showed a significant role of phage therapy in reduction of deaths in the bacterial pneumonia models as compared to the placebo group. However, after 48hrs, a non-significant reduction was observed.

Conclusion

There was a significant role of phage therapy in the reduction of deaths in the bacterial pneumonia models.

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2024-02-14
2025-04-02

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Phage Therapy in Bacterial Pneumonia Models: A Systematic Review and Meta-Analysis
Comb Chem High Throughput Screen 28, 447 (2025); https://doi.org/10.2174/0113862073267755240126111628
/content/journals/cchts/10.2174/0113862073267755240126111628
/content/journals/cchts/10.2174/0113862073267755240126111628
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PRISMA checklist is available as supplementary material on the publisher’s website along with the published article.

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  • Article Type:     Research Article
Keyword(s): bacterial pneumonia; meta-analysis; mortality; Phage therapy; preclinical studies; systematic review

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