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Volume 28, Issue 3
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

Amines are important and valuable compounds widely used in the chemical industry to produce various products such as dyes, detergents, solvents, additives, pharmaceutical products, and anti-foam agents. A property that distinguishes primary amines from other compounds is their straightforward functionalization. Therefore, the synthesis of different amine compounds has been considered by many researchers in recent years. Usually, primary amines are produced amination of alcohols, reductive amination, and reduction of nitro and amide compounds. Furthermore, a useful and atom-economical method for producing primary amines is reducing nitrile compounds using catalytic systems. Traditionally, nitriles are reduced using metal hydrides such as LiAlH or NaBH. These methods have important restrictions in terms of selectivity and waste generation. Hence, the heterogeneous and homogeneous catalysts were investigated for the hydrogenation of nitriles to diverse amines. This review describes the performance of different catalytic systems for reducing nitrile compounds to their corresponding amines.

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Recent Advances in Catalytic Systems for the Reduction of Aromatic and Aliphatic Nitrile Compounds to Amines
Comb Chem High Throughput Screen 28, 392 (2025); https://doi.org/10.2174/0113862073284975240324091848
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  • Article Type:     Review Article
Keyword(s): aliphatic nitrile compounds; Amines; heterogeneous catalysis; homogeneous catalysis; hydrogenation; nitriles; reduction

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