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image of Optimization and Characterization of Mucoadhesive Buccal Films using Mimosa Seed-based Natural Polymer for Controlled Drug Release: A Sustainable Approach

Abstract

Background

The present study attempted to develop cost-effective, biocompatible and biodegradable mucoadhesive buccal films exploring and using seed polymer, marking its potential as a sustainable drug delivery in pharmaceutical development.

Methods

The extracted polymer was characterized for solubility, viscosity, loss on drying, pH, swelling index, starch, and mucilage ingredients. Compatibility between the polymer, drug, and excipients was assessed using FTIR analysis. Buccal film trial batches were formulated using the film casting technique and were optimized using the 23 full factorial design. Optimized formulation was characterized for drug release, permeability, mucoadhesive study, similarity, and difference factor along with histological and stability study.

Results

The polymer’s pH, loss on drying, swelling index, and viscosity were 6.2, 6.8%, 81.77%, and 50,000 cP respectively. FTIR studies showed the compatibility between natural polymer, the model drug metoprolol succinate, and the excipients used. The early trial batches of polymeric films showed an extended drug release comparable to the standard polymers with a good permeability flux of 0.4048 ± 0.081 mcg*cm-2*h-1. The optimized film provided a controlled release of 52.31 ± 0.035% for more than 8 h following zero order kinetics. Mucoadhesive strength was found to be 32.25 ± 0.29 g. The similarity factor and difference factor (8.197) indicated no significant difference compared to the standard formulation. Histological study demonstrated the non-irritant nature of the films and stability was established from the stability studies.

Conclusion

Thus, a sustainable approach using natural polymeric buccal films was found promising for mucoadhesion and controlled release.

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2024-09-11
2024-11-26

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/content/journals/caps/10.2174/0124522716331619240830064412
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Optimization and Characterization of Mucoadhesive Buccal Films using Mimosa Seed-based Natural Polymer for Controlled Drug Release: A Sustainable Approach
Bentham Science Publishers ; https://doi.org/10.2174/0124522716331619240830064412
/content/journals/caps/10.2174/0124522716331619240830064412
/content/journals/caps/10.2174/0124522716331619240830064412
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  • Article Type:     Research Article
Keywords: mucoadhesive ; Buccal ; mimosa ; swelling index ; films ; natural polymer
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