Introduction Metformin induces radiation sensitivity in cancer cells including colorectal cancer cells; however the exact molecular mechanisms underlying its radiosensitive effects are not yet known. In this study we investigated the role of the p53/miR-34a/SIRT1 pathway in the radiosensitivity of colon cancer cells. Methods The study was carried out from 2020 to 2022 at the Qazvin University of Medical Science's Cellular and Molecular Research Center. Two c Read More

Objective: This study aimed to explore the diagnostic value of multiorgan (heart lungs blood vessels) point-of-care ultrasound (PoCUS) in patients with high-risk and medium-to-low-risk pulmonary embolism (PE). Methods: Clinical data of 92 patients with suspected PE admitted to Hangzhou TCM Hospital affiliated with Zhejiang Chinese Medical University from July 2021 to June 2023 were retrospectively analyzed. According to hemodynamic status patients w Read More

Purpose: This study aims to develop an accurate image registration framework for personalized respiratory motion modeling. Methods: The proposed framework incorporates longitudinal data through a two-stage transfer learning approach. In the first stage transfer learning is employed on longitudinal data collected from the same device. In the second stage a personalized model is constructed using the transfer learning approach reusing the model f Read More

Background: The neuroanatomical basis of white matter fiber tracts in gait impairments in individuals suffering from Parkinson’s Disease (PD) is unclear. Methods: Twenty-four individuals living with PD and 29 Healthy Controls (HCs) were included. For each participant two-shell High Angular Resolution Diffusion Imaging (HARDI) and high-resolution 3D structural images were acquired using the 3T MRI. Diffusion-weighted data preprocessing was performed Read More

Objective: The aim of this study was to develop and validate predictive models for perineural invasion (PNI) in gastric cancer (GC) using clinical factors and radiomics features derived from contrast-enhanced computed tomography (CE-CT) scans and to compare the performance of these models. Methods: This study included 205 GC patients who were randomly divided into a training set (n=143) and a validation set (n=62) in a 7:3 ratio. Optimal radiomics Read More

Background: Multiple sclerosis (MS) is one of the most common disabling central nervous system diseases affecting young adults. Magnetic resonance imaging (MRI) is an essential tool for diagnosing and following up multiple sclerosis. Over the years many MRI techniques have been developed to improve the sensitivity of MS disease detection. In recent years synthetic MRI (sMRI) and quantitative MRI (qMRI) have gained traction in neuroimaging appl Read More

Background: Colon diseases are major global health issues that often require early detection and correct diagnosis to be effectively treated. Deep learning approaches and recent developments in medical imaging have demonstrated promise in increasing diagnostic accuracy. Objective: This work suggests that a Convolutional Neural Network (CNN) model paired with other models can detect different gastrointestinal (GI) abnormalities or diseases from endo Read More

Background: Primary intracranial Ewing Sarcoma/peripheral Primitive Neuroectodermal Tumor (EWS/pPNET) is exceedingly rare and easy to misdiagnose. Case Presentation: We present a case involving a 23-year-old male who presented with headaches and vomiting. The preoperative brain imaging revealed an irregular mass in the left parietal lobe initially misdiagnosed as meningioma. However the surgical specimen was ultimately diagnosed as primary i Read More

Background: The effects of percutaneous compression plate (PCP) internal fixation for femoral neck fractures (FNFs) in elderly individuals have rarely been reported. Therefore this study aimed to investigate the efficacy of PCCP internal fixation for displaced FNFs in elderly individuals based on imaging. Methods: The clinical data of 32 elderly patients with FNFs treated with PCCP from January 2015 to December 2022 were retrospectively analyzed. The aver Read More

Objectives: The objective of this study was to summarize the findings of children’s intracranial congenital or developmental malformations found during imaging procedures in the Tibetan plateau. Methods: We retrospectively reviewed the imaging data of the suspected patients who presented with the central nervous system (CNS) malformations and were enrolled either through the clinic or after ultrasound examinations between June 2019 and June 20 Read More