BackgroundIn the pharmaceutical sciences the solubility profile of therapeutic molecules is crucial for identifying and formulating drugs and evaluating their quality across the drug discovery pipeline based on factors like oral bioavailability metabolic transformation biodistribution kinetics and potential toxicological implications. The investigation aims to enhance the solubility parameters of ketoprofen (BCS-II class) which exhibits low solubility and high permea Read More

ObjectivesZirconium-89 (89Zr t1/2=3.27d) is an important β+ emitting radionuclide used in Positron Emission Tomography (PET) immuno studies due to its unique characteristics and increased demand due to simple and cost-effective production capacity. Production of 89Zr is achieved primarily through solid natural yttrium targets via different target preparation methodologies such as electrodeposition pressed foils and spark plasma sintering. In this st Read More

BackgroundGated SPECT is an established technique for assessment of left ventricular function in cardiovascular disease patients. However there is little information about the influence of diabetes mellitus on gated SPECT parameters. This study was established to assess gated SPECT parameters in Diabetes Mellitus (DM) and non-diabetes mellitus (non-DM) patients with normal Myocardial Perfusion Imaging (MPI).MethodsIn this analytical cross-sectiona Read More

Aim: This research aims to develop and evaluate a novel health classification and severity detection system based on Vision Transformers (ViTs) for fetal ultrasound imagery. This contributes to improved precision in fetal health status detection and abnormalities with more accurate results than other traditional models. Background: Amidst the other imperatives of resource-deficient developing nations mitigating neonatal mortality rates is a challenge that Read More

Objective: This study aimed to develop and assess the performance of a YOLOv8 algorithm-aided detection model for identifying rib fractures on multiplane reconstruction (MPR) images addressing the limitations of current AI models and the labor-intensive nature of manual diagnosis. Methods: Ethical approval was obtained and a dataset comprising 624 MPR images confirmed by CT was collected from three regions of Tongji Hospital between May 2020 a Read More

Background: There remains a lack of methods to accurately assess the efficacy of neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Objective: This study aimed to investigate the value of shear-wave elastography in evaluating the treatment response to neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Materials and Methods: This prospective observational study enrolled 275 patients with locally advanced rectal can Read More

Background: An effective preoperative diagnosis between minute pulmonary meningothelial-like nodules (MPMNs) and adenocarcinoma in situ (AIS) can provide clinicians with appropriate treatment strategies. Objective: This study aimed to differentiate MPMNs from AIS via computed tomography (CT) radiomics approaches. Methods: Clinical and imaging data from fifty-one patients diagnosed with MPMNs and 55 patients diagnosed with AIS were Read More

Background: Delphian lymph node (DLN) metastasis is common in papillary thyroid cancer (PTC). However few studies have specifically investigated the clinicopathologic characteristics of DLN metastasis in PTC. This study aimed to examine the incidence risk factors and predictive value of DLN in papillary thyroid carcinoma. Methods: In the present study the clinicopathologic features and metastatic risks were statistically analyzed by reviewing 1837 Read More

Introduction A promising material used in radiation synovectomy of small joints is hydroxyapatite labeled with 177Lu. During the design and production of radiopharmaceuticals the condition of the radiolabeling process directly influences the radiochemical yield and consequently the quality of the final product so this process necessitates precise optimization. Methods In this investigation a central composite design based on response surface methodolog Read More

Dementia (the most common cause of Alzheimer's disease) is defined as a chronic or progressive syndrome with disturbance of multiple cortical functions the most important of them including memory learning capacity comprehension orientation calculation language and judgement. These cognitive impairments affect the quality of life behavior and social relations. Techniques of nuclear medicine provide feasible ways to record the intracellula Read More