Journal of Current Toxicology and Venomics - Volume 4, Issue 1, 2024

BackgroundThe detection of microcystins in blood, respiratory mucosa, and urine samples to diagnose acute or chronic microcystin intoxication is difficult and requires sophisticated analysis techniques. Finding simple and quick methods to assess the exposure of individuals to microcystins is crucial.ObjectiveThis study aims to assess the presence of specific antibodies (IgG, IgE, IgA, and IgM) against microcystin-LR in individual Read More

A potential source of multiple enzymatic and nonenzymatic molecules that protect the host is snake venom. In these venoms, several kinds of peptides that have significant beneficial effects were discovered and characterized. Disintegrins act by blocking integrins on transmembrane cell surfaces, inhibiting tumor cells from adhering, migrating, forming new blood vessels, and spreading. This has an important effect on del Read More

BackgroundAcetaminophen overdose is a leading cause of acute liver failure globally. Current treatment options, primarily N-acetylcysteine (NAC), have limitations. Mito-TEMPO (Mito-T), a mitochondria-targeted antioxidant, has shown potential in preclinical studies. This systematic review evaluated the evidence for Mito-T's hepatoprotective effects against acetaminophen-induced liver injury.MethodsWe conducted a compr Read More

BackgroundSpices, including Amomum subulatum and Coriander sativum, are not only popular for improving food flavour but are also accepted worldwide for their health benefits in various disorders.ObjectiveThis study aimed to elucidate the possible mechanism for the anti-apoptotic effect of terpene-rich extract of Amomum subulatum and Coriandrum sativum against the rodent model of cardiotoxicity.MethodsEffects of st Read More

BackgroundSome neurotoxins inhibit nerves strongly. Saxitoxins and tetrodotoxin exhibit strong affinity for various voltage-gated sodium channels (VGSCs), including Nav 1.7, but low affinity for Nav 1.8. Emerging data suggests AGAP mediate analgesia by binding voltage-independently to sodium channel site-3.ObjectiveThis study examined AGAP's mechanism and analgesic efficacy during sciatic nerve block.MethodsIn rats Read More

The issue of snakebite continues to be a distinctive matter of public health in various regions across the globe, with a particular emphasis on India, where the ailment is widely prevalent. Snakebites in the country disproportionately affect rural and indigenous populations, resulting in some of the highest morbidity and mortality rates worldwide. Regrettably, in numerous tropical nations, the accessibility of antivenom is frequently p Read More

BackgroundMore than 80% of the world's population uses herbal remedies in some form. Heavy metal contamination and the attendant health risks of Indian herbal medicines are not adequately documented.ObjectiveThis study aimed to investigate the health risks associated with four common heavy metal contaminants, namely lead, arsenic, cadmium, and mercury, present in raw medicinal herbs cultivated or growin Read More

BackgroundCrotalus durissus cumanensis (C.d.c.) is the most widely distributed snake in Venezuela, causing the majority of snakebite envenoming.ObjectiveThe purpose of this study was to produce IgY antibodies against a C.d.c. venom pool from different Venezuelan regions and evaluate their neutralization capacity on various venom toxic activities.MethodsAnti-C.d.c. venom antibodies are purified from chicken e Read More

BackgroundIn India and other tropical nations, snake bites are a serious public health issue that anti-snake venom may effectively treat.Case PresentationThe case report described here details the antivenom received to neutralize the toxins present in Russell’s viper venom, followed by Ayurveda treatment to remove the surgical wound and reduce joint stiffness by applying Ayurvedic paste prepared by Laportea aestuan Read More

Buthus martensii Karsch (BmK) scorpion venom and its extracts are compounds found to contain a mixture of peptides with antitumor and analgesic activities. The extracts also contain polypeptides, lipids, nucleotides, mucoproteins, and other unknown substances showing potential therapeutic application. Finding medically relevant toxins, a range of peptides have been purified from BmK scorpion venom. These scor Read More

BackgroundEnvenomation with Odontobuthus doriae scorpion results in pain at the bite site, inflammation, necrosis, and neurotoxicity. Administration of anti-scorpion antiserum prepared from immunized horses is the main therapy for envenomation. However, in some cases, anaphylactic shock related to antiserum administration limits its use. Therefore, the identification of the venom component and the dev Read More

IntroductionSpiders are predators that use their venom to immobilize their prey. These spider toxins are able to affect the central nervous system of mammals.MethodsWe hypothesized that venom from the tarantula Vitalius platyomma may induce behavioral changes in male Wistar rats. To test this hypothesis, the behavioral effects of venom were investigated after intracerebroventricular microinjection using the neuroethol Read More

IntroductionVenom allergens have been identified in the venom of scorpion, snake, bee, wasp, etc. Some allergy reactions in humans may refer to the venom allergens.AimPhylogenetic analysis of venom allergens from the transcriptome of Hemiscorpius lepturus scorpion was the main aim of the study.MethodsSeven venom allergens: HLAllergen1, HLAllergen2, HLAllergen3, HLAllergen4, HLAllergen5, HLAllergen6, and HLAllerg Read More

BackgroundSnakebites are a worldwide health problem and produce pathological symptoms, such as hemorrhage, tissue necrosis, blood coagulation disorder, edema, and death. Although serum therapy protects victims from death, it does not prevent amputation of the affected limb. Therefore, alternative treatments deserve attention.ObjectiveTo test a new series of twelve disubstituted triazoles, TRI 02, TRI 03, TRI 04 Read More