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Volume 4, Issue 1
  • ISSN: 2950-5704
  • E-ISSN: 2950-5712

Abstract

Introduction

Spiders are predators that use their venom to immobilize their prey. These spider toxins are able to affect the central nervous system of mammals.

Methods

We hypothesized that venom from the tarantula may induce behavioral changes in male Wistar rats. To test this hypothesis, the behavioral effects of venom were investigated after intracerebroventricular microinjection using the neuroethological method (behavioral sequences) associated with the program, evaluating frequency, duration, and strength of statistical association between pairs (dyads) of behaviors.

Results

The results obtained in this present study showed that the intracerebral administration of crude venom provoked a difference in the time of freezing of animals. In addition, animals showed after the freezing period changes in the exploratory and grooming clusters and additional complex sequences of behaviors such as wild running.

Conclusion

This study clearly demonstrated the appearance of seizure-like behaviors, similar to audiogenic brainstem-dependent seizures such as those observed in genetically-selected audiogenic strains.

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2024-01-01
2024-11-22

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Neuroethological Analysis of the Effects of Venom of the Spider Vitalius Platyomma (Theraphosidae, Theraphosinae) Microinjected into the Lateral Ventricle of Wistar Rats
J. Curr. Toxicol. Venomics 4, E291123223992 (2024); https://doi.org/10.2174/0126661217263227231103050833
/content/journals/jctv/10.2174/0126661217263227231103050833
/content/journals/jctv/10.2174/0126661217263227231103050833
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  • Article Type:     Research Article
Keyword(s): convulsions; epilepsy; freezing; seizures; Spider toxin; wild running
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