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Volume 14, Issue 4
  • ISSN: 2210-3031
  • E-ISSN: 2210-304X

Abstract

Aim

The research was carried out to develop the microemulsion-loaded gel of curcumin, alkylpolyglucoside, and tea tree oil to treat vulvovaginal candidiasis infection.

Methods

Screening of oils, surfactants, and co-surfactants was done based on solubility studies and the construction of pseudo-ternary phase diagrams with curcumin. The microemulsion was characterized for globule size, zeta potential, viscosity, and thermodynamic stability. studies were carried out using Franz diffusion cells. The antifungal activity of microemulsion-loaded hydrogel was evaluated using the cup plate method using Candida albicans ATCC 10231 in glucose yeast agar medium.

Results

The selected micro-emulsion consisted of curcumin 35µg/mL, IPM+TTO (1:1) 0.1 mL, Milcoside 100 + Acconon MC 8-2 EP NF 0.6-0.3 mL, phosphate buffer pH 4 160 mL showed maximum thermodynamic stability and exhibited lowest particle size and highest intensity. The viscosity of microemulsion-loaded gel was 11.2 pa.s. The surface tension of the microemulsion was measured by tensiometer and was found to be 26.07 mN/m. Antimicrobial susceptibility testing assay was done according to NCCLs assay protocol, and the EC50 value of our formulation was found to be 0.4465 μg/mL. drug release and permeation studies showed 67.9% release in 420 minutes and 83.02% release in 360 minutes, respectively. An irritation study concluded that there was no redness or irritation on goat mucosa.

Conclusion

The texture analysis test showed adhesiveness at -172.46 g s at - 4.60 adhesive force, and the peak load was 13.40 g. The microemulsion-loaded gel formulation can be a promising alternative to the marketed formulations available for vaginal yeast infections.

© 2024 Bentham Science Publishers
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2024-12-01
2024-11-22

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/content/journals/ddl/10.2174/0122103031304658240627063415
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Development of Novel Women's Friendly Antifungal Microemulsion Loaded Gel for Vulvovaginal Infections
Drug Deliv Lett 14, 308 (2024); https://doi.org/10.2174/0122103031304658240627063415
/content/journals/ddl/10.2174/0122103031304658240627063415
/content/journals/ddl/10.2174/0122103031304658240627063415
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  • Article Type:     Research Article
Keyword(s): alkylpolyglucoside; Antifungal; curcumin; microemulsion loaded gel; tea tree oil; vulvovaginal infections
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