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- Volume 28, Issue 32, 2022
Current Pharmaceutical Design - Volume 28, Issue 32, 2022
Volume 28, Issue 32, 2022
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Fourth Generation of Synthetic Cannabinoid Receptor Agonists: A Review on the Latest Insights
Authors: Sara Malaca, Francesco P. Busardò, Giulio Nittari, Ascanio Sirignano and Giovanna RicciBackground: Over the past few years, an emerging number of new psychoactive substances (NPSs) entered the illicit market. NPSs are designed to resemble the effects of classical drugs of abuse, reinforcing their effects and duration. Among the most abused NPS, synthetic cannabinoids are cannabinoid receptor agonists (SCRAs) that mimic the effect of the main psychotropic phytocannabinoid Δ9-tetrahydrocannabinol (THC). Read More
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GC-MS Identification and Quantification of the Synthetic Cannabinoid MDMB-4en- PINACA in Cannabis-derived Material Seized in the Turin Metropolitan Area (Italy)
Authors: Enrico Gerace, Fabrizio Seganti, Daniele Di Corcia, Marco Vincenti and Alberto SalomoneBackground: The presence of the synthetic cannabinoid receptor agonist MDMB-4en-PINACA in adulterated low-THC cannabis products was recently highlighted in several reports. Moreover, numerous intoxication cases involving MDMB-4en-PINACA have been described. Objective: In order to monitor the diffusion of cannabis products containing MDMB-4en-PINACA in our territory, a total of 358 cannabis-derived sampl Read More
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Determination of Traditional and Designer Benzodiazepines in Urine through LC-MS/MS
Authors: Brian Rossi, Francesca Freni, Claudia Carelli, Matteo Moretti, Dario Galatone, Claudia Vignali and Luca MoriniBackground: The detection of new designer benzodiazepines in biological fluids and tissues, together with the traditional ones, could represent an important analytical update for laboratories performing clinical and forensic toxicological analysis. Objective: A liquid chromatography tandem mass spectrometry method (LC-MS/MS) has been developed, fully validated, and applied to a cohort of real urine samples collected fro Read More
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Designer Benzodiazepines' Activity on Opioid Receptors: A Docking Study
Background: Previous studies have reported that benzodiazepines (BZDs) seem to enhance euphoric and reinforcing properties of opioids in opioid users so that a direct effect on opioid receptors has been postulated, together with a possible synergistic induction of severe side effects due to co use of BDZs and opioids. This is particularly worrisome given the appearance on the market of designer benzodiazepines (DBZDs), whos Read More
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Brain Concentrations of MDPV and its Metabolites in Male Rats: Relationship to Pharmacodynamic Effects
Background: MDPV (3,4-methylenedioxypyrovalerone) is a synthetic stimulant that blocks transmitter uptake at transporters for dopamine and norepinephrine. Less is known about MDPV pharmacokinetics, especially with respect to brain concentrations of the drug and its metabolites. Objectives: The goal of the present study was: 1) to determine brain concentrations of MDPV and its metabolites, 3,4-dihydroxypyrovale Read More
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An Insight to Heat Shock Protein 90: A Remedy for Multiple Problems
Authors: Megha Yadav, Ankit K. Singh, Adarsh Kumar, Suresh Thareja and Pradeep KumarHeat shock protein 90 (Hsp90) is a chaperone protein that prevents many other proteins from aggregating by folding them in a certain way. Hsp90 consists of three structural domains: N-terminal, middle and C-terminal domains. Hsp90 has many activities in numerous proteins and signaling pathways like chimeric fusion proteins, steroid hormone receptors, tumor suppressor genes, and cell cycle regulatory proteins. The role Read More
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The Role of Heat Shock Protein 27 in Carcinogenesis and Treatment of Colorectal Cancer
Authors: Fereshteh Asgharzadeh, Reyhaneh Moradi-Marjaneh and Mahdi M. MarjanehThe incidence of colorectal cancer (CRC) has significantly increased in recent decades, which has made this disease an important global health issue. Despite many efforts, there is no useful prognostic or diagnostic biomarker for CRC. Heat shock protein 27 (Hsp27) is one of the most studied members of the Hsp family. It has attracted particular attention in CRC pathogenesis since it is involved in fundamental cell functions for Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
- Issue 46
- Issue 45
- Issue 44
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- Issue 2
- Issue 1
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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