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- Volume 28, Issue 31, 2022
Current Pharmaceutical Design - Volume 28, Issue 31, 2022
Volume 28, Issue 31, 2022
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Narrative on Hydrogen Therapy and its Clinical Applications: Safety and Efficacy
Molecular hydrogen proved itself as a novel therapeutic candidate and has been thriving from the beginning with its potential clinical significance, higher affinity, and cellular integrity and permeability. Hydrogen Therapy (HT) has gained scientists' attention with the proven clinical ability to attenuate chronic inflammation, diminish oxidative stress, restrict apoptosis, minimize cellular injury, and refine tissue functioning. Ther Read More
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Self-emulsifying Drug Delivery System for Oral Anticancer Therapy: Constraints and Recent Development
Authors: Mrugank Pandya, Bappaditya Chatterjee and Srikar GantiOral anticancer therapy faces several drawbacks: low aqueous solubility, poor and irregular absorption from gastrointestinal sites, high first-pass metabolism, food-influenced absorption, non-targeted delivery, severe systemic and local adverse effects, etc. Enhancement of oral bioavailability could reduce the drug load and associated adverse effects. Self-emulsifying drug delivery systems (SEDDS) can enhance in-vivo solubilit Read More
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Recognizing, Managing and Treating Acute Agitation in Youths
Authors: Virginio Salvi, Laura Orsolini, Lorenzo M. Martino, Simone Pompili and Umberto VolpeAcute agitation is common in youths presenting to emergency departments, and, in some cases, may escalate into aggression and violence. Therefore, acute agitation in youths should be immediately and appropriately recognized and treated to avoid the consequences of its escalation. Agitation is widespread in youths, reported in around 7% of all youths admitted to emergency departments due to psychiatric reasons. Read More
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Isorhamnetin: A Novel Natural Product Beneficial for Cardiovascular Disease
Authors: Wen-Qing Li, Jing Li, Wen-Xiu Liu, Liu-Jun Wu, Jun-Yuan Qin, Zi-Wei Lin, Xin-Yu Liu, Shi-Yan Luo, Qing-Hua Wu, Xiao-Fang Xie and Cheng PengCardiovascular disease (CVD) has become a severe threat to human beings with increasing morbidity and mortality. Isorhamnetin (Iso) shows multiple bioactivities, especially in the cardiovascular system. A literature retrieval strategy was conducted in databases of PubMed, GeenMedical, Sci-Hub, Web of Science, China National Knowledge Infrastructure (CNKI), and Baidu Scholar, with keywords defined as: "Isorhamnetin", Read More
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The Inhibitory Effect on Tumor Cells Proliferation Induced by Arsenic Through DNMTs and its Downstream Molecules: A Systematic Review and Meta-Analysis
Authors: Jingyi Zhang, Sheng Li, Mingxiao Ma and Shugang LiBackground: We aimed to systematically evaluate the regulatory effect of arsenic on DNMTs and its downstream molecules in tumor cells and to provide a theoretical framework revealing the specific mechanism of arsenic in the treatment of tumors. Methods: Meta-analysis was performed using RevMan 5.3 and Stata 12.0, and differences between groups were described as standardized mean difference. Results: We found o Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
- Issue 46
- Issue 45
- Issue 44
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- Issue 42
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- Issue 2
- Issue 1
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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