Current Pharmaceutical Design - Volume 28, Issue 30, 2022

Alzheimer’s disease accounts for a high percentage of dementia cases in elderly individuals. This type of brain disease is caused by damage to the brain cells affecting the ability of the patients to communicate, as well as their thinking, behavior, and feelings. Although numerous research laboratories focus on advancements in treating Alzheimer’s disease, the currently approved pharmacological approaches seem to only Read More

Background: Nucleic acid-based carbohydrate sensors (NAbCSs) constitute a strategy involving nucleic acids as recognition elements for the development of a unique, stable, sensitive, mono- or multimodal detection system in the field of nanomedicine, gas sensing, and gene therapy. Thus, this advanced platform for next-generation investigation compromises cost-effective, wearable, and noninvasive sensing devices Read More

Feeding pattern is related to health status or chronic diseases, and this depends on the individual’s eating habits. Feeding organized with the right time to start and end during the day, promotes an internal biological rhythm, favoring molecular synchronization of the clock genes, which impose an effect on metabolism and immune cells, creating a physiological response related to a healthy profile. On the other hand, a feeding p Read More

Background: The presentation of 3D printing in drug innovation especially focuses on the advancement of patient-centered dosage forms based on the structural design. Rising interest for customization of 3D printed inserts during surgeries combined with developing R speculations is driving the medical services. 3D printing technique is considered emerging digitized technology and it is beneficial for the future progression and de Read More

Background: Acute lung injury (ALI) is a serious respiratory disease with a high mortality rate, and there is an urgent need for a more effective treatment strategy. Andrographolide derivative AL-1 has been identified to possess anti-inflammatory activity. However, whether it could reduce LPS-induced lung injury in mice through inhibiting NLRP3 inflammasome activation and protecting lung permeability has not yet been elu Read More