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- Volume 28, Issue 20, 2022
Current Pharmaceutical Design - Volume 28, Issue 20, 2022
Volume 28, Issue 20, 2022
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Requirements for Translation in Clinical Trials of Aromatherapy: The Case of the Essential Oil of Bergamot (BEO) for Management of Agitation in Severe Dementia
Due to the tight link between undertreated pain and agitation in dementia patients, aromatherapy can be a useful approach if an essential oil (EO) with powerful analgesic activity is used. The methodological difficulties of most aromatherapy trials have not allowed any definitive conclusion about the effectiveness of aromatherapy in dementia. The objective of the present perspective is to illustrate the long rigorous process l Read More
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Luliconazole Topical Dermal Drug Delivery for Superficial Fungal Infections: Penetration Hurdles and Role of Functional Nanomaterials
Luliconazole is the first and only anti-fungal agent approved for the short-term treatment of superficial fungal infections. However, commercially available conventional topical dermal drug delivery cargo of luliconazole is associated with certain limitations, like lower skin permeation and shorter skin retention of drug. Therefore, the present review is an attempt to unravel the penetration hurdles in luliconazole topical der Read More
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Recent Advancement of Polymersomes as Drug Delivery Carrier
Authors: Kuldeep Singh, Avadh Biharee, Amber Vyas, Suresh Thareja and Akhlesh K. JainBackground: Biomedical applications of polymersomes have been explored, including drug and gene delivery, insulin delivery, hemoglobin delivery, the delivery of anticancer agents, and various diagnostic purposes. Objectives: Polymersomes, which are self-assembled amphiphilic block copolymers, have received a lot of attention in drug delivery approaches. This review represents the methods of preparation of polymer Read More
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Role of Drug Delivery System in Improving the Bioavailability of Resveratrol
Authors: Zonish Saleem, Kanwal Rehman and Muhammad Sajid Hamid AkashResveratrol (RSV) is a natural polyphenolic compound known for its therapeutic activities but has limited bioavailability. The aim of our study was to explore various drug-delivering methods that are being employed to achieve target-oriented delivery and therapeutic performance of RSV. To improve the bioavailability and pharmacokinetic properties of RSV, efforts are being made to produce efficient formulations accompanyi Read More
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Recent Advances in the Surfactant and Controlled Release Polymer-based Solid Dispersion
Authors: Aman Gupta, Gourav Paudwal, Rigzin Dolkar, Shaila Lewis and Prem N. GuptaThe oral route is the most preferred delivery route for drug administration due to its advantages, such as lower cost, improved patient compliance, no need for trained personnel, and less severity of drug reactions in general. The major problem with new molecules in the drug discovery pipeline is poor solubility and dissolution rate that ultimately results in low oral bioavailability. Numerous techniques are available for solubility an Read More
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Beta Blockers can Mask not only Hypoglycemia but also Hypotension
Background: Beta-adrenergic (β-AR) receptor blockers (BBs) are an essential class of drugs as they have numerous indications. On the other hand, they have numerous unwanted effects that decrease the compliance, adherence, and persistence of this very useful group of drugs. Objective: The paper aims to analyze the possibility that an unnoticed side effect may contribute to a less favorable pharmacologic profile of BBs, e.g., Read More
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Biomedical Applications of Carbohydrate-based Polyurethane: From Biosynthesis to Degradation
Authors: Jahan A. Batool, Kanwal Rehman, Abdul Qader and Muhammad S. H. AkashThe foremost common natural polymers are carbohydrate-based polymers or polysaccharides, having a long chain of monosaccharide or disaccharide units linked together via glycosidic linkage to form a complex structure. There are several uses of carbohydrate-based polymers in the biomedical sector due to their attractive features, including less toxicity, biocompatibility, biodegradability, high reactivity, availability, an Read More
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MEG8: An Indispensable Long Non-coding RNA in Multiple Cancers
Authors: Zhuoying Du, Fangshun Tan, Jinlan Chen, Bei Wang, Yuling Liu, Fangnan Zhao, Yinxin Wu and Chengfu YuanBackground: As a member of long non-coding RNAs (lncRNAs), maternally expressed gene 8 (MEG8) has been found involving in the progression of a variety of cancers and playing a regulatory role. Therefore, MEG8 may turn into a new therapeutic target for cancer in the future. The purpose of this review is to illustrate the molecular mechanism and physiological function of MEG8 in various cancers. Methods: We retrieved and a Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
- Issue 46
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- Issue 2
- Issue 1
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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