Current Pharmaceutical Design - Volume 28, Issue 22, 2022

Coronavirus disease 2019 (COVID-19) continues to spread globally despite the discovery of vaccines. Many people die due to COVID-19 as a result of catastrophic consequences, such as acute respiratory distress syndrome, pulmonary embolism, and disseminated intravascular coagulation caused by a cytokine storm. Immunopathology and immunogenetic research may assist in diagnosing, predicting, and treating severe C Read More

Defined by the World Health Organization as a global public health pandemic, coronavirus 2019 (COVID-19) has a global impact and has caused the death of thousands of people. The “severe acute respiratory syndrome coronavirus 2” virus (SARS-CoV-2) is the etiologic agent of this disease, which uses the angiotensinconverting enzyme receptor 2 (ACE2) to infect the body, so any organ that expresses the gene ACE2 is a pos Read More

The release of cytokines and chemokines such as IL128;1β, IL-2, IL-6, IL-7, IL-10, TNF-α, IFN128;γ, CCL2, CCL3, and CXCL10 is increased in critically ill patients with COVID-19. Excessive cytokine release during COVID-19 is related to increased morbidity and mortality. Several mechanisms are put forward for cytokine release syndrome during COVID-19. Here we have mentioned novel pathways. SARS-CoV-2 increases angiotensin II Read More

Polysaccharides (PSs) of plant origin have a variety of biological activities, including antiatherosclerotic, but their use in atherosclerosis therapy is hindered by insufficient knowledge based on the cellular and molecular mechanisms of action. In this review, the influence of several natural PSs on the function of macrophages, viral activity and macrophage cholesterol metabolism has been discussed, considering the tight interplay Read More

Background: Genetically modified micro-organisms like bacteria, viruses, algae and fungi are novel approaches used in the field of healthcare due to better efficacy and targeted delivery in comparison to conventional approaches. Objectives: This review article focuses on the applications of genetically modified micro-organisms in the treatment of cancer, obesity and HIV infection. The gut microbiome causes metabolic disor Read More

Background: Various anticancer drugs are effective therapeutic agents for cancer treatment; however, they cause severe toxicity in body organs. Cardiotoxicity is one of the most critical side effects of these drugs. Based on various findings, turmeric extract has positive effects on cardiac cells. Objective: This study aims to evaluate how curcumin, as the main component of turmeric, may affect chemotherapy- induced cardiotoxi Read More

Background: Docosahexaenoic acid-acylated phloridzin (PZ-DHA), a novel polyphenol fatty acid ester derivative, is synthesized through an acylation reaction of phloridzin (PZ) and docosahexaenoic acid (DHA). PZ-DHA is more stable than DHA and exhibits higher cellular uptake and bioavailability than PZ. Objective: The study aims to investigate the effects of PZ-DHA on insulin resistance in the skeletal muscle and the related mech Read More