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- Volume 28, Issue 16, 2022
Current Pharmaceutical Design - Volume 28, Issue 16, 2022
Volume 28, Issue 16, 2022
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Sex Differences in Therapies for Heart Failure
Authors: Davor Miličić, Maria Bergami and Saša PavasovićHeart failure (HF) is a common cause of morbimortality with different etiopathogenesis and prognosis between men and women. This review provides a brief overview of gender-based differences in response to pharmacological therapies of heart failure with or without reduced ejection fraction (EF). It focuses on the differences in therapy outcomes with angiotensin-converting enzyme inhibitors (ACEi), angiotensin recept Read More
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Bioactive Compounds and Diabetes Mellitus: Prospects and Future Challenges
Diabetes mellitus is a metabolic condition that influences the endocrine framework. Hyperglycemia and hyperlipidemia are two of the most widely recognized metabolic irregularities in diabetes and two of the most well-known reasons for diabetic intricacies. Diabetes mellitus is a persistent illness brought about by metabolic irregularities in hyperglycemic pancreatic cells. Hyperglycemia can be brought about by an absence Read More
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Hippo: A New Hub for Atherosclerotic Disease
Authors: Xi-Yan Liu, Kun Zhou, Kai-Jiang Tian, Bin-Jie Yan, Zhong Ren, Zhi-Xiang Zhou, Wen-Hao Xiong and Zhi-Sheng JiangHippo, an evolutionarily conserved kinase cascade reaction in organisms, can respond to a set of signals, such as mechanical signals and cell metabolism, to maintain cell growth, differentiation, tissue/organ development, and homeostasis. In the past ten years, Hippo has controlled the development of tissues and organs by regulating the process of cell proliferation, especially in the field of cardiac regeneration after my Read More
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Preclinical and Clinical Aspects of using Tazemetostate in Human Cancers
Authors: Leila Mousazadeh, Behzad Mousazadeh, Jamshid Motaei, Faezeh Abbasi and Reza J. EsfehaniEpigenetic drugs are novel drug categories with promising effects in different cancers. Tazemetostate is among the drugs that were recently used in clinical settings, especially in the treatment of specific tumors and lymphomas. There are a growing number of ongoing clinical trials evaluating the safety and efficacy of tazemetostate in different cancers. The present review addressed the available preclinical studies evaluating t Read More
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FER1L4: A Long Non-coding RNA with Multiple Roles in the Occurrence and Development of Tumors
Authors: Jie Mou, Bei Wang, Yuling Liu, Fengnan Zhao, Yinxin Wu, Wen Xu, Deyuan Zeng, Qi Zhang and Chengfu YuanBackground: FER-1 family member 4 (FER1L4), a 6.7 kb lncRNA located at 20q11.22, plays an important biological function in a variety of tumor diseases. The purpose of this review is to clarify the pathophysiological mechanism and potential biological function of FER1L4 in different tumors. Methods: By searching the relevant literature in PubMed, the specific pathophysiological mechanism of FER1L4 in different tumors was s Read More
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NEAT1: A Novel Long Non-coding RNA Involved in Mediating Type 2 Diabetes and its Various Complications
Authors: Dengke Jia, Yaping He, Yaqi Wang, Mengzhen Xue, Leiqi Zhu, Fangqi Xia, Yuanyang Li, Yan Gao, Luoying Li, Silong Chen, Guangfu Xu and Chengfu YuanBackground: Nuclear128;enriched abundant transcript 1 (abbreviated as NEAT1) is a long-chain noncoding RNA involved in various physiological and pathological processes. This study aimed to clarify the effect and molecule system of NEAT1 within non-alcoholic fatty liver disease (NAFLD) as well as type 2 diabetes (T2DM). Methods: In this review, current studies concerning mechanisms of NEAT1l, in the development of type 2 Read More
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Metformin has no Significant Anticancer Effect on Patients with Advanced or Unresectable Cancer: A Systematic Review and Meta-analysis
Authors: Xinyan Gan, Chang Cao, Yan He, Xiaolin Hu, Xingchen Peng and Yonglin SuBackground: At present, the antitumor effect of metformin is controversial. Previous meta-analyses included observational studies, of which the results can be influenced by many confounders, affecting the result of meta-analyses and weakening the strength of evidence. Therefore, we conducted a meta-analysis to confirm the effect of metformin use on patients with advanced or unresectable cancers, including random Read More
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The Effect of Ramosetron on Remifentanil in Preventing Emergence Cough from Sevoflurane Anesthesia in Female Patients
Authors: Ji Ho Kim, Ga Yun Lee, Hye S. Lee and Sung Yong ParkBackground: Remifentanil reduces cough during extubation. Ramosetron, a 5-HT3 receptor antagonist, is a potent antiemetic. Regarding the antitussive property of 5-HT receptor agonists, ramosetron can mediate the cough reflex by increasing the remifentanil requirement. This study evaluated the effect of ramosetron on the optimal effect-site concentration (Ce) of remifentanil for preventing emergence cough from s Read More
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Captopril and Spironolactone can Attenuate Diabetic Nephropathy in Wistar Rats by Targeting ABCA1 and microRNA-33
Background: Nephropathy diabetes is one of the important causes of death and a more prevalent cause of end-stage renal disease. Objective: The present study investigated the effect of applying spironolactone and captopril and their combination on some renal performance indices and cholesterol-efflux-related gene expression in nephropathy diabetic rats. Methods: Intraperitoneal injection of streptozotocin was used to Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
- Issue 46
- Issue 45
- Issue 44
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- Issue 1
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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