Current Organic Chemistry - Volume 19, Issue 16, 2015

As both trifluoromethylthio (CF3S) and trifluoromethoxy (CF3O) moieties have proved to be valuable functionalities in pharmaceutical chemistry, trifluoromethylthiolation and trifluoromethoxylation have received a great deal of attention. For the trifluoromethylthiolation reaction, a variety of efficient methods have been developed. Among these methods, C-H trifluoromethylthiolation avoids the need to prefunctionalize substr Read More

Because of the lack of naturally occurring pathways to form C-F bonds, and the high toxicity and/or explosive nature of the fluorination reagents (HF and F2), chemists have to seek alternative reagents and relevant fluorination and fluoroalkylation methods to construct oragnofluorides that we widely use today. The direct transition-metal mediated/catalyzed trifluoroethylation of organic scaffolds, such as arylboronic acids or est Read More

The difunctionalization of unsaturated carbon-carbon double bond is a powerful strategy for the construction of compounds with various functional groups. The present review aims to highlight the recent developments in the fluorination of alkenes with concomitant introduction of additional functional groups. Various methods are described for both intramolecular and intermolecular fluorofunctionalization of alkenes. These fl Read More

During recent 30 years, successful efforts have been made to develop useful electrophilic fluorinating and fluoroalkylating reagents in spite of the difficulty of generating fluorine cation (F+) and fluoroalkyl cation (F-C+). With this advancement, a wide variety of reactions between these reagents and organometallics have been reported as one of the most straightforward ways to introduce fluorinated functional groups. T Read More

The utility of pentafluorosulfanyl (SF5)-containing compounds has been limited because the chemistry has not been fully explored. While significant attention has been focused on the incorporation of fluorine in C-F bonds, or the introduction of a trifluoromethyl (CF3) groups, our attention has been focused on the SF5 group. The SF5 group has a similar electron withdrawing effect as the CF3 group yet the SF5 group is significan Read More

Synthetic methods for the enantioselective constructions of trifluoromethylated stereogenic centers are described. In particular, this review focuses on recent examples of catalytic enantioselective transformations with trifluoromethyl alkenes. These reactions efficiently synthesized chiral compounds with trifluoromethylated stereogenic centers.

Impressive progress has been achieved during the past decade in the incorporation of various fluroinecontaining groups, especially lightly fluorinated groups, into organic compounds. Among them, the introduction of difluoromethyl group into a compound commonly brings about many special and important effects. Two major strategies have been developed: (1) direct transfer of a CF2H group into target molecules (dire Read More