Current Organic Chemistry - Volume 19, Issue 2, 2015

The Review reports the recent developments of palladium-catalyzed nucleophilic substitution of allylic alcohols and allylic amines used as electrophiles. The poor ability of the hydroxyl and amino groups to serve as good leaving groups has been overcome by the employment of additives which promote the palladium-catalyzed C-N and C-O bond cleavage. However, allylic alcohol and amine activation can be achi Read More

Transition-metal-catalyzed direct C-H bond functionalizations have attracted considerable attention around the world for almost half a century. In the past decades, great efforts have been made for the development of late transition metals, mainly due to some advantages in terms of the diversity and high efficiency of the catalysts. However, their application was limited on account of their relatively high price, low natural Read More

Aryltriazenes have emerged as highly powerful and versatile building blocks in a variety of synthetic transformations, which attracted extensive attentions due to their advantages of good reactivity, well stability, ready availability, operational simplicity and diverse transformation. In this review, we summarize the current progresses involving aryltriazenes as starting materials or active intermediates for various synthetical Read More

Functionalized benzocycloheptenes are one of the most important classes of bicyclic framework that have been critically investigated in different areas of biological activities. Due to interesting skeleton and activities, synthetic chemists were inspired to synthesize them for better understanding of the basic knowledge associated with these compounds. Thus, this review aims to provide insight approaches for construction and fun Read More

The Hirao reaction, an important tool for the establishment of a P-C bond, was developed further by finding that the reaction of >P(O)H species, such as dialkyl phosphites, alkyl phenyl-H-phosphinates and diarylphosphine oxides with bromoarenes may be carried out in the presence of P-ligand-free NiCl2 as the catalyst. The scope and limitations of this “greener” approach was studied in detail.