Current Organic Chemistry - Volume 19, Issue 13, 2015

Microorganisms produce a large number of peptide-based natural products that display a broad range of biologically interesting properties, including antimicrobial, immunosuppressant, and anticancer activities, as well as behaving as virulence factors and signaling molecules. These peptide natural products are composed of proteinogenic amino acids, as well as a number of other compound classes, including non-pr Read More

The studies on the reaction of arynes with the π-bond are limited, although synthetic chemistry using aryne has attracted substantial attention. This review highlights the insertion of arynes into the π-bond giving the formal [2+2] cycloaddition-type adducts. In this review, the synthetic organic reactions involving the [2+2]-type reactions of arynes with the carbon-carbon double bond, the carbon-heteroatom double bond and th Read More

The excellent advantages of cesium such as short reaction times, small amount of reagent used, high yields of the products, milder reaction conditions, and easy work-up procedures counter balanced its higher cost. From the last two decades, the use of cesium salts has received an increasing interest in numerous varieties of synthetic conversions. Today, the use of cesium salts has reached the industrial acceptance. Read More

During the past few decades, polymer nanocomposites have gained momentum for designing materials that exhibit synergistic properties by overcoming the inherent limitations of pure materials particularly conducting polymers (CPs). Clays have been extensively employed as hosts for developing intercalated nanocomposites. The growth of conducting polymers in the interlayer region of the clays has shown to dramatic Read More

In this paper we report a new strategy for the synthesis of isoindolo[2,1-b]isoquinolines. N-(1,2- Diphenylethyl)acetamides prepared from the corresponding deoxybenzoins were used as starting material. Double cascade cyclization of the amides promoted by oxalyl chloride and stannyl chloride afforded the oxidized isoindolo[ 2,1-b]isoquinolinone derivatives, which by reduction with a BH3·THF complex gave the 5,7,11b,1 Read More