Current Organic Chemistry - Volume 19, Issue 15, 2015

Due to its unique anatomy, drug delivery to eye structures has always been problematic. Many efforts have been addressed to enhance ocular bioavailability by lowering non-specific interactions between drug and tissue, increasing drug stability or increasing the residence time in the case of topical drugs. In this context, nanotechnology has been a very helpful tool for developing suitable drug delivery systems. More specificall Read More

Despite incredible advancement made in recent years, treatment of cancer still remains the most challenging task for the mankind. The new small molecule therapeutic drugs are more specific, exhibit better therapeutic efficacy and mostly contain scaffolds of β-lactam, sulfonamide, quinoline, quinazoline, quinoxaline, purine, pyrimidine, resorcinol, pyrazole/isoxazole, benzamide etc. The structure-activity relationships of differe Read More

The Birch reduction is unique, in synthetic approaches, due to the adaptable substitution patterns of the substituted cyclohexa-1,4- and 1,3-dienes, particularly enol ethers. Birch reduction as a key and sometimes as the only reduction tool has found several applications in total synthesis of several natural occurring compounds. This name reduction is very important and quite useful for reduction of aromatic and none-aroma Read More

In the framework of our general interest on the reactivity and on the pharmacological activity of heterocyclic compounds, we have examined the behaviour of some variously substituted 5- and 6-nitroindazoles. Remembering that nitroreduction processes are often essential steps for their biological activity we have collected NMR, ESR, and CV data and carried out DFT computations to gain a deep picture of electronic distri Read More