Current Organic Chemistry - Volume 19, Issue 9, 2015

The Horner-Wadsworth-Emmons reaction is one of the most reliable and widespread synthetic tools for the stereocontrolled construction of ethylenic bonds. The versatility of the reaction makes it a valuable synthetic tool to prepare simple as well as densely functionalized and complex molecular scaffolds. This review is devoted to the recent evolution of the reaction, which considerably widens its product scope and synt Read More

Vinyl azides have emerged as important synthons in recent years and a variety of |useful synthetic methodologies have been achieved in the construction of the nitrogen heterocycles, such as indoles, pyrroles, imidazoles, pyrazoles, pyridines and pyrimidines. The unstable azide group and the presence of neighboring unsaturated double bond accentuate the high reactive ity of vinyl azides with other electrophiles and nucle Read More

This review focuses on the catalytic activity of the organic bicyclic amidine base, 1,8-diazabicyclo [5.4.0]undec-7-ene (DBU). It is available commercially, cheap and a homogenous catalyst. It has been used widely in a variety of reactions viz. elimination, esterification, cyclisation, condensation, multicomponent reactions etc.

In recent years, utilizing water as a clean, safe, readily available and almost free of charge solvent for the syntheses of a broad spectrum of organic compounds has been comprehensively realized and proven. At first glance, it seems that water is proposed as a green replacement for the harmful and evaporable organic solvents; however, in some cases, it presents exclusive reactivity and selectivity, which could not be ac Read More