- Home
- A-Z Publications
- Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Central Nervous System Agents)
- Fast Track Listing
Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Central Nervous System Agents) - Online First
Description text for Online First listing goes here...
12
results
-
-
Identification of Pharmacophore Responsible for the JNK3 Enzyme Inhibition using KPLS-based QSAR Analysis
Authors: Ravi Kumar Rajan, Maida Engels and UmaaKuppuswamyAvailable online: 03 March 2025More LessBackground The pharmacophoric approach relies on the theory of possessing ubiquitous chemical functionalities, and carrying a uniform spatial conformation that provides a route to enhanced potency on the same target receptor. JNK3, also known as c-Jun N-terminal kinase 3, is a protein kinase that plays a crucial role in various cellular processes, particularly in the central nervous system (CNS). In this study, a kernel-base Read More
-
-
-
Role of Liposomes in the Treatment of Neurodegenerative Disorders: A Comprehensive Review
Available online: 29 January 2025More LessThe complex etiology and limited therapy options of neurodegenerative illnesses pose daunting challenges to modern medicine. Nonetheless, novel treatment approaches have exciting new possibilities because of developments in nanotechnology. Liposomes have garnered a lot of interest as a potential treatment for neurological illnesses due to the fact that they are able to adapt to their role as nanocarriers. This review article Read More
-
-
-
The Importance of Stem Cells in the Treatment of Neuropathic Pain
Available online: 03 December 2024More LessMany disorders, including heart, bone, cancer, liver, and brain disease, have been treated using stem cell therapy as a viable alternative. The somatosensory system is affected by a lesion, which leads to neuropathic pain (NP), and just a relatively tiny fraction of patients now receive effective care from existing pharmacological medications. There have been studies to show the effectiveness of various stem cells in re Read More
-
-
-
Phthalates Induced Neurotoxicity: A Mechanistic Approach
Authors: Kajal Gaur and Yasir Hasan SiddiqueAvailable online: 03 December 2024More LessPhthalates play a significant role as plastic modifying additives in everyday items like plastics, pesticides, paints, and cosmetics. This review explores the relationship between phthalates and neurotoxicity and sheds light on the potential risks these ubiquitous chemicals pose to neurological health. The review elucidates the diverse neurotoxic effects of phthalates exposure, spanning developmental neurotoxicity, Read More
-
-
-
Neuroprotective Effect of Naturally Occurring Flavonoids
Available online: 03 December 2024More LessFlavonoids have a wide range of neuroprotective effects on the brain, including the capacity to reduce neuroinflammation, shield neurons from harm caused by neurotoxins, and maybe improve memory, learning, and cognitive function. These functions are most likely a result of two similar mechanisms. Inhibiting neurotoxic substance-induced apoptosis and promoting synaptic plasticity and neuronal survival are achieved by Read More
-
-
-
Antidepressant Potential of Hispidulin Present in S. barbata D. Don: Mechanistic Insights through Neurochemical and Behavioral Assessments
Authors: Arzoo Pannu, Ramesh K. Goyal and Shikha GoswamiAvailable online: 04 November 2024More LessBackground and Aim This study aims to investigate the antidepressant properties of Hispidulin, a flavonoid present in Scutellaria barbata D. Don. The selection of Hispidulin stems from its notable inhibitory activity against Xanthine Oxidase (XO), a parameter in the pathophysiology of depression. Material and Methods Mice were subjected to a rigorous evaluation using a murine model of Chronic Unpredictable Mild Stre Read More
-
-
-
Identification of Phytoconstituents from Natural Product Database as SIRT2 Inhibitors for Potential Role in Alzheimer’s Disease: An In-Silico Screening
Authors: Hitesh Kumar, Ashok Kumar Datusalia, Anoop Kumar and Gopal L. KhatikAvailable online: 24 October 2024More LessAim We aimed to conduct in silico screening of the potential phytoconstituent from a natural product database to find SIRT2 inhibitors. Background Alzheimer's disease (AD) is the most prevalent type of dementia, characterized by behavioral and mental symptoms as well as a progressive loss of cognitive ability. Since SIRT2 may be detrimental to neurological illnesses, it is a prime target for research into SIRT2 inhibitors. Objective Read More
-
-
-
Thiazolidine-4-one Analogues: Synthesis, In-Silico Molecular Modeling, and In-vivo Estimation for Anticonvulsant Potential
Available online: 22 October 2024More LessBackground Epilepsy is a critically deep-rooted CNS disorder affecting above 50 million people all over the world. Thus, a safe and effective treatment that proves its worth in this ailment is urgently needed. Thiazolidine-4-ones possess the molecules to be used as anticonvulsants. The thiazolidinedione is a cyclic analogue of thiosemicarbazides and thioureas as well as a (bio)isostere of hydantoin (imidazolidine-2,4-dione Read More
-
-
-
Novel Emerging Targets Identification in Reducing Risk of Alzheimer’s Disease
Authors: Saurabh Sharma, Kalpana Rahate and Rahul KumarAvailable online: 21 October 2024More LessThe accumulation of tau-containing neurofibrillary tangles and beta-amyloid deposits has been identified as the hallmark of Alzheimer's disease. Alzheimer's disease (AD) is a hereditary and neurological condition that can result in non-amnestic cognitive decline in less common forms and amnestic memory loss in its classic form. While Alzheimer's disease is the most prevalent cause of memory loss in middle-aged and olde Read More
-
-
-
A Brief Review on Caenorhabditis elegans Role in Modelling Neurodegenerative Disease
Authors: Himangi Vig, Priyanka Shukla, Anamika Mishra, Ayushi Pal and Ankita WalAvailable online: 16 October 2024More LessA small, translucent nematode known as Caenorhabditis elegans, or C. elegans, is frequently utilized as a model organism in biomedical studies. These worms, which are around 1 mm long and feed on bacteria, are usually found in soil. For accessible and effective research on genetics, developmental biology, neuroscience, cell biology, and aging, C. elegans provide an ideal model. Its simplicity, which includes a transluc Read More
-
-
-
To Explore Nasal-Brain Lymphatic System for Brain-Targeted Drug Delivery and to Treat Neurodegenerative Diseases
Authors: Rohit Sharma, Monika, Bobby Tyagi, Disha Gupta, Rupa Mazumder and Avijit MazumderAvailable online: 15 October 2024More LessBrain-related Neurodegenerative Disorders (NDD) are the leading cause of low life expectancy globally. Brain-targeted drug delivery is required for treating most the NDD via bypassing the blood-brain barrier, and hepatic first-pass metabolism. The nasal-brain drug delivery route has the advantage of locally enhancing drug delivery to the brain, mainly through the olfactory route rather than systemic circulation. To overco Read More
-
-
-
Nattokinase Attenuated Excitatory Amino Acids and Cytokines Release and Restored Cerebral Blood Fflow in a Thrombolytic Focal Cerebral Ischemic Rat Model
Authors: M Ramanathan, Mohammed Jamshir KM, Jerin M Jose and Nidhya GanesanAvailable online: 09 October 2024More LessObjective Nattokinase (NK), a protease enzyme present in traditional fermented Japanese food, has shown fibrinolytic properties in vitro as well as in cardiac ischemia. In the present study, the Neuroprotective effect of standardized NK was evaluated in the thrombolytic focal cerebral ischemic model. Methodology The parameters of behavioural assessment, cerebral blood flow, inflammatory mediators, excitatory amino acids, Read More
-