Current Bioactive Compounds - Volume 19, Issue 9, 2023

Background: Cancer has turned into a health issue that requires the most rapid attention. Because of the disease's global reach and the high number of deaths it causes, research and development of novel anticancer treatments that are both effective and have fewer adverse effects is crucial. According to a 2015 survey by the World Health Organization (WHO), Cancer kills 8.8 million people each year, accounting for 60 Read More

Background: An arbovirus called the Zika virus is spread by Aedes mosquitoes. The Zika virus (ZIKV) epidemic that has recently spread over the Western Hemisphere (the Americas and the ongoing outbreak in Brazil) is now recognised as one of the main causes of neurologic disease and other potential neurologic consequences. Methods: There are currently no antivirals available, and vaccines are only available for some. Read More

Background: Naregamia alata is an endemic herb of Western Ghats with traditional medicinal uses and pharmacological activities, viz. anti-inflammatory, antioxidant, antipyretic, hepatoprotective and antidiabetic effects. However, no information is available on the phytoconstituents of N. alata responsible for antidiabetic activities. Objective: Isolation and identification of compound/s from the dichloromethane fraction of Read More

The liver is an essential organ that aids in the metabolism and elimination of xenobiotics from the body and dysfunction of the liver is a serious health issue that concerns physicians, pharmaceutical companies, and regulatory bodies. The effects of numerous hazardous substances, particularly antibiotics, chemotherapeutics, carbon tetrachloride (CCl4), thioacetamide (TAA), and microorganisms on liver cells have be Read More

Background: Discovery of novel anti-cancer drugs from natural origin has increased tremendously due to the resistance of multiple chemotherapeutic drugs in breast cancer therapy and its high toxicity to undesirable side effects. Objective: The aim of the study was to investigate the bioactivity of secondary metabolites derived from Actinobacteria sp. BACSAS14 isolated from a vegetable farm in Vellore, Tamil Nad Read More

Background: Because of their biological properties, phytochemicals have been essential to nutraceutical treatment for diabetes mellitus. Various phytoconstituents derived from Tinospora are reported to have immunomodulatory, anti-arthritis, antioxidant, anti-allergic cardio, and oxidatively- induced stress protection. Objectives: This study aimed to identify and characterize the key phytoconstituents of Tinospora cordifolia for Read More

Kaempferol, a natural flavonoid found in numerous fruits, vegetables, and herbs, possesses many pharmacological activities such as antioxidant, anti-inflammatory and anti-cancer. Kaempferol has low aqueous solubility and hence has poor oral bioavailability. Numerous promising techniques were used to enhance its absorption and structural transformation to deliver kaempferol. Novel pharmaceutical technologies, including Read More

Background: The present research aimed to assess the relationship between free radical scavenging activity and oral hypoglycemic potential of methanol extract of the root of Cryptolepis buchanani in Albino Wistar rats. Objective: The following research aimed to study and evaluate the antidiabetic efficacy of the natural plant extracts Cryptolepis buchanani. Methods: Phytochemical screening was done to analyze, and in Read More

Background: In recent years, 2-aminobenzothiazoles were reported as antibacterial, antihelmintic, antitumor, antimalarial, antiviral, analgesic and anti-inflammatory agents. Objectives: The study aimed to explore new potential 2-aminobenzothiazoles as antibacterial and anthelmintic agents. Methods: A favorable two-step method was used for the synthesis of new 2-aminobenzothiazole derivatives (4a-4j) by Schiff base. All syn Read More