Current Bioactive Compounds - Volume 19, Issue 7, 2023

Silymarin, a flavonolignan derived from the seeds extract of Silybum marianum (milk thistle), has been frequently used since ancient times. It is made up of flavonolignans such as silychristin, isosilybin A and B, dehydrosilybin, and silybin as well as flavonoids like taxifolin, with silibinin being the most active. Silibinin is a diastereoisomeric combination of two flavonolignans, silybin A and silybin B, with a diastereoisomeric struct Read More

Background: Hemorrhoids are anorectal disorders characterized by dilation of rectal blood vessels, inflammation, and prolapse of the anal tissue. The disease affects both men and women equally. In consequence, the increasing prevalence of the disease needs potential agents with efficiency and low cost to support the treatment. Objective: The treatment of hemorrhoids in modern medicine is still found to be in its infancy, as Read More

Background: The aim of our study was to investigate the mechanisms of oil-related product toluene and functional food flaxseed Linum usitatissimum L. on ovaries in humans and the potential protective effect of flaxseed against adverse toluene action. We examined 1) the action of toluene (at doses 0, 10, and 100 ng/ml), 2) flaxseed extract (10 μg/ml), and their combination on cultured human ovarian granulosa cells Read More

Garcinia indica (also known as kokum) is a small evergreen tree that has been used in a variety of culinary, industrial, and pharmacological products, as well as fruit juices and food. In the present study, the antioxidant capacity of anthocyanin extracted from Garcinia indica fruit waste was assessed using DPPH, ABTS assay, and a Caenorhabditis elegans infection model. The independent variables, such as temperature, Read More

Aims: To investigate the effect of R. hypocrateriformis extract on the production of proinflammatory cytokines by macrophages. Background: The whole plant was extracted with ethanol at room temperature. The in vitro antiinflammatory activity of RH was investigated on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Objective: LPS-induced nitric oxide (NO) production was determined by the Griess method. Pr Read More

Background: Calotropis procera (Aiton) (Apocynaceae) is a traditional Indian medicinal plant and used in folk medicine for the past decade for the treatment of gastrointestinal disorders. Therefore the current investigation was undertaken to explore the gastroprotective effect of C. procera (Aiton) leaves extract using pylorus ligation-induced gastric ulcer in rats. Methods: The crude powder material was successively extracte Read More

Background: Disturbances in the sleep cycle have been often associated with the depletion of oxidant enzymes and deposition of beta-amyloid plaques leading to neurodegeneration in Alzheimer's disease (AD). Healthy sleep time and sleep cycles were proven to clear the betaamyloid out of the brain and also promote the synthesis and functions of anti-oxidant enzymes. Objective: Jasmonic acid was evaluated to enhance the Read More

Withania somnifera (Ashwagandha) is one of the most renowned and revered medicinal plants in the Indian Ayurvedic system of medicine. Ashwagandha Rasayanas (tonics), capsules, tablets, and powdered herbs (churna) have been used for curing a wide variety of ailments, including reproductive problems, and for improving fertility in men and women as well as erectile dysfunction (ED) in men. Iron accumulation in r Read More