Current Bioactive Compounds - Volume 19, Issue 5, 2023

Aim: The aim of the study was to characterize and investigate the mechanism of action of anti-hyperglycemic and anti-hyperlipidemic constitutents of Allophylus africanus. Background: Allophylus africanus P. Beauv is a medicinal plant commonly used in sub-Sahara Africa for the treatment of metabolic disorders and infectious diseases. Objective: The objective of the study was to isolate and characterize anti-hyperglycemic an Read More

Hesperidin has gained major interest recently due to the outbreak of COVID-19. The traction has led to more research being conducted on the compound hesperidin. Recent studies have shown its anti-inflammatory and anti-viral attributes, which have beneficial effects on severe acute respiratory syndrome (SARS-CoV-2). Hesperidin has also shown unique effects on the protein of SARS-CoV-2, which lead to a good preve Read More

Background: A member of the Malvaceae family, Azadirachta indica (Neem) is wellknown for its secondary metabolites, including limonoids, flavonoids, triterpenoids, and tetraterpenoids. These compounds have been studied for decades for their bioactivities, including antihemorrhagic and antiproteolytic, which provide information about the use of triterpenoids. Methods: Gedunin was purified by chromatography after b Read More

Lung cancer is often associated with the second leading cause of mortality in males globally. Despite clinical advancements, their incidence in humans has not decreased. Hence identifying and developing alternative or complementary therapeutic agents with evidence targeting lung cancer is of considerable interest. Ursolic Acid (UA): a dietary flavonoid present in herbs, vegetables, and fruits can effectively alleviate t Read More

One of the critical issues that humans worldwide are facing is bacterial infections. Antibiotics were developed as bactericidal agents to avoid the negative consequences of bacterial infections, and they were initially highly efficient against bacteria. However, we face a phenomenon called antibiotic resistance by misusing these chemical antibiotics in this era. In other words, bacteria began to acquire resistance to common Read More

Background: Hepatoprotectors, currently used in clinical practice, often show low efficacy. One of the promising goals in the therapy of liver diseases is the targeted synthesis of smallmolecule drugs with hepatoprotective activity. Some heterocycles, such as 1,4-dihydropyridines, are proven to be good hepatoprotectors. Objective: This study aimed to prepare and investigate the hepatoprotective effects of some dihyd Read More

The limiting restrictions for any chemical to pass through cellular membranes and be absorbed systematically after oral or topical administration are the molecular size and lipid solubility. Herbal materials are used to make Phytosomes, a new drug delivery method that is easy to make and has a high absorption profile. The pharmacological profile of the drug is also excellent. Due to low lipid solubility and insufficient molecular si Read More