Evaluation of in vitro Antioxidant and Hypoglycemic Activities of Methanol Extract of Root of Cryptolepis buchanani in Streptozotocin-induced Diabetic Rats

Background: The present research aimed to assess the relationship between free radical scavenging activity and oral hypoglycemic potential of methanol extract of the root of Cryptolepis buchanani in Albino Wistar rats. Objective: The following research aimed to study and evaluate the antidiabetic efficacy of the natural plant extracts Cryptolepis buchanani. Methods: Phytochemical screening was done to analyze, and in vitro, the antioxidant activity of plant root extract has been evaluated using DPPH assay and Fe⁺³ Reducing Power Assay. Streptozotocin at a 60 mg/kg dose was used to induce diabetes in albino Wistar rats, which was then treated with methanol extracts (125 and 250 mg/kg, PO) to evaluate antidiabetic activity. Results: The results indicated that methanol extract of the root of Cryptolepis Buchanan had shown its promising antidiabetic potential at a dose of 250 mg/kg in experimental diabetic Wistar rats, which may be linked to its antioxidant property. Conclusion: This experimental study revealed that the extract could potentially alleviate the augmented oxidative state correlated with diabetes. The marked reduction in blood glucose levels proves the hypoglycemic activity of the plant.