Current Bioactive Compounds - Volume 19, Issue 2, 2023

Background: Glodok fish (Boleophthalmus boddarti) was identified to contain bioactive compounds such as steroids, terpenoids, bufadienolid, carotatoksin, and corticosteroids. These compounds benefit human life, and Lampung coastal communities consume the fish to cure asthma. Various processing methods, such as frying, are used to prepare the fish. The frying process can damage vitamins, proteins, and bioacti Read More

Background & Aims: The incidence of cardiovascular disease in climacteric women has increased, becoming the main cause of death in mature women. The use of phytoestrogens, isoflavones, and lignans derived from soy and flaxseed can be natural alternative treatments for this phase of life. This study investigates the utility of isoflavones and lignans derived from soy and flaxseed as natural alternatives to pharmaceutical Read More

Background: An alkylating agent named cyclophosphamide (CP) is an immunosuppressant used in the therapy of rheumatoid arthritis and various cancers. The combination of curcumin and quercetin was evaluated for antioxidant activity against CP-induced renal oxidative stress in Wistar rats. Methods: A prophylactic treatment using a combination of curcumin and quercetin is given to the rats at 80 mg/kg and 200 mg/kg (b.w.) Read More

Background: Putoria calabrica is a common Mediterranean plant used topically in folk medicine for medical purposes. The aim of this study is to evaluate the in vitro antioxidant, antibacterial, and antihemolytic properties of Putoria calabrica leaf extracts. Methods: Total phenol content (TPC), total flavonoid content (TFC), and condensed tannins content (CTC) were determined spectrophotometrically. The antioxidant activity wa Read More

Background: The number of life-threatening diseases like “Candidiasis” is rapidly increasing worldwide. The effective management of the disease is indeed a great challenge for the clinician. Objectives: In an approach to developing effective antifungal compounds for growing fungal diseases, the present study was conducted to investigate the antifungal activity of selected medicinal plants collected from district Mardan. Methods: Read More

Background: Linum usitatissimum is widely used in traditional medicine for the treatment of inflammation, and cardiovascular and respiratory diseases. Methods: Acute oral toxicity and anti-inflammatory and analgesic effects of total alkaloid extract from Linum usitatissimum seeds (ALU) were investigated in vivo. Xylene-induced ear edema was used to determine the anti-inflammatory effect, and acetic acid-induced writhi Read More

Background: Inflammation is a natural biological response of the body tissues to harmful stimuli, such as damaged cells, irritants or pathogens, and it is a protective response involving blood vessels, immune cells and molecular mediators. Activator Protein-1 (AP-1) is a dimer composed of both homo and hetero dimers with jun and fos subfamilies. The heterodimer cfos-cjun complex is upregulated in several inflammatory diseas Read More

Background: Chrysopogon zizanioides Roberty root extracts have documented amylase and α-glucosidase inhibition, hepatoprotection, antioxidant, antimicrobial, antihyperglycemic, antidepressant, and antitubercular properties but lack ample reports on health care applications of purified phytoconstituents. Objective: To study the inhibitory properties of phytosterol eluate against cholesterol esterase (CEase) and diabetic fo Read More

Malaria is one of the deadliest vectors of spreading diseases, which causes enormous health concerns in the tropical world, especially in sub-Saharan countries. Despite tremendous efforts around the globe, malaria is one of the leading causes of death in those areas. In addition, the appearance of resistance to the currently available drugs is making the situation more alarming, which highlights the urgency for contin Read More