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image of Polymeric Microspheres for Herbal Extract Encapsulation: Advanced Formulation Techniques, Biomedical Applications, and Future Prospects

Abstract

Microspheres are tiny spherical particles with a diameter of 1 to 1000 μm that play a key role in several industries, most notably medicine delivery. This article provides an extensive overview of polymeric microspheres, including information on their uses, advantages, disadvantages, and various forms. We pay special attention to mucoadhesive microspheres and those containing herbal medicines. Improved bioavailability, regulated release patterns, and increased medicinal efficiency of plant extracts are among the important discoveries. Microspheres can be roughly categorized as either synthetic or natural. Synthetic microspheres provide targeted distribution and controlled medication release. One example of a synthetic microsphere is a biodegradable polymer called poly(lactic-co-glycolic acid) (PLGA). They might, however, run into restrictions like burst discharge and difficulties increasing production. On the other hand, natural microspheres made of substances like albumin or starch provide biocompatibility and easy disintegration, but they might not give you exact control over the kinetics of drug release. One subset of microspheres, known as mucoadhesive microspheres, has attracted a lot of attention due to its capacity to stick to mucosal surfaces, increasing bioavailability and extending the duration of drug residence. A variety of polymers, such as chitosan and alginate, which have strong adhesive qualities to mucosal tissues, can be used to create these microspheres. Moreover, the integration of herbal medicines into polymeric microspheres has several benefits, such as increased stability, regulated release, and better therapeutic effectiveness. To sum up, microspheres show great promise as a drug delivery platform. Particular benefits include increased bioavailability, controlled release, and targeted therapy for mucoadhesive microspheres and those containing herbal medicines. This article provides an in-depth review of polymeric microspheres, highlighting their various forms, benefits, drawbacks, and uses, with a particular focus on mucoadhesive microspheres and those encapsulating herbal medications. Key findings include enhanced bioavailability, controlled release profiles, and improved therapeutic efficacy of herbal extracts.

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2025-01-30
2025-07-05

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/content/journals/caps/10.2174/0124522716338115241226033817
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Polymeric Microspheres for Herbal Extract Encapsulation: Advanced Formulation Techniques, Biomedical Applications, and Future Prospects
Bentham Science Publishers ; https://doi.org/10.2174/0124522716338115241226033817
/content/journals/caps/10.2174/0124522716338115241226033817
/content/journals/caps/10.2174/0124522716338115241226033817
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  • Article Type:     Review Article
Keywords: regulated release biodegradable polymer ; polymer ; stability ; synthetic polymer ; Mucoadhesive ; microspheres ; herbal

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