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Study of Drug Release of Diclofenac Sodium Matrix Tablets Using Synergistic Effect of HPMC and Xanthan Gum Polymer
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- 14 Aug 2024
- 20 Nov 2024
- 30 Jan 2025
Abstract
Aims
To check the release efficacy of active pharmaceutical ingredients from tablet dosage form using synthetic and natural polymers.
Background
Diclofenac sodium in sustained release manner tablets was created by Xanthan gum, HPMC, and mixed with both polymers to change the concentration ratio. The dosage form of the tablet was examined for the early stage formulation studies such as repose angle, apparent density, compressibility index, and some corporal properties like weight variant, friability, and content of the drug. For post-formulation studies, like in-vitro studies were implemented in a solution of phosphate buffer pH 7.4 for 8 hours. All the corporal properties of the diclofenac sodium tablets were within the limit of tolerance.
Objective
The study checked the Diclofenac Sodium release kinetics from synthetic and natural polymer-modified tablets.
Method
Following the wet granulation method, we prepared a diclofenac sodium tablet using HPMC and Xanthan Gum Polymer
Result
The tablet that contained both HPMC and Xanthan gum (Batch C-I and C-II) shows the best drug content than other polymer-based batches like HPMC (Batch A-I, A-II) and Xanthan gum (Batch B-I, B-II). The great sustained drug release was shown in the HPMC and Xanthan gum mixed polymer-based matrix tablet (Batch C-I). The data showed that the mixing of polymers could lead to sustaining drug release from the formulation.
Conclusion
From the research, we can conclude that the diclofenac release % was maximum when we used a combination of both polymers in the tablet dosage form.
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