Anti-Infective Agents - Online First

Background Sesquiterpene coumarins are a unique class of natural compounds with a wide range of biological activities. These C15 terpenes are connected by ether or carbon-carbon bonds to coumarin derivatives. Sesquiterpene coumarins that include a 7-hydroxylcoumarin (umbelliferone) moiety have significant antiviral properties. The natural flexibility of these compounds reduces the likelihood of developing resistance, w Read More

Human Immunodeficiency Virus (HIV) is a retrovirus that is well known to be the causative agent for acquired immunodeficiency syndrome. In this review, we discussed the HIV virus, its transmission, events that lead to AIDS, the historical aspect of its emergence, current prospects in antiretroviral drugs, and its evolution up until current treatment strategies. We have also discussed the recent research related to new Read More

Background Heterocyclic compounds play an essential role in biological systems and occur widely in nature. They are fundamental in the development of pharmaceuticals aimed at combating microbial infections and other” with “with the potential biological activities. Pharmacological evaluations have demonstrated their efficacy against diverse bacterial strains. This study investigates the antimicrobial properties of var Read More

Nipah virus (NiV), a bat-borne infection, was first identified in Malaysia 20 years ago and has since caused outbreaks in South and Southeast Asia. NiV leads to severe respiratory and neurological conditions, is often fatal, and is highly contagious, spreading through close contact with infected individuals or animals. The virus exhibits varied clinical and epidemiological traits, necessitating rapid infection control measures to prev Read More

Background The urgent need for new antimicrobial compounds arises from the growing threat of multidrug-resistant human pathogens responsible for infectious diseases. The indole moiety, a prevalent heterocyclic ring system found in nature, is a key structural element in many pharmaceutical agents due to its wide range of biological activities. Bis(indolyl)methanes, in particular, have emerged as promising candidates for antib Read More

The Marburg virus (MARV), which belongs to the family Filoviridae, is the cause of Marburg virus disease (MVD), a disease that can be fatal. Laboratories employees of Marburg and Frankfurt cities of Germany, and Belgrade city of Yugoslavia (now Serbia), contracted an infection caused by a hitherto unidentified infectious pathogen in August 1967. According to the World Health Organization (WHO), MARV is one of the m Read More

Introduction Cancer, diabetes, and infection of bacteria and fungi are serious issues in the world. Synthesis of the potential drugs against them is a major challenge to the researcher. Hence, coordination chemistry has attracted researchers as it has various applications in medicinal and biological fields. Methods Synthesis and biological evolution of azo-Schiff base ligand and its Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and VO(II) Read More

BackgroundMicrobes are a rich source of antibacterial and anti-insect molecules. Due to rising antibiotic and anti-insect resistance in various sectors of the society, it is important to identify new compounds that may address these issues.Aims and ObjectiveThis study aimed to explore the bacteria isolated from soil to identify new molecules with antibacterial and anti-insect activity. Further, the current study is aimed at testi Read More