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image of Synthesis, Characterization, and Anticancer, Antidiabetic, and Antimicrobial Activities of Azo-Schiff Base Ligand with ONO Donor Atom and its Transition Metal Complexes

Abstract

Introduction

Cancer, diabetes, and infection of bacteria and fungi are serious issues in the world. Synthesis of the potential drugs against them is a major challenge to the researcher. Hence, coordination chemistry has attracted researchers as it has various applications in medicinal and biological fields.

Methods

Synthesis and biological evolution of azo-Schiff base ligand and its Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and VO(II) metal complexes were carried out. These compounds were characterized by Mass, 1H-NMR, FT-IR, Elemental analysis, Molar conductance, Magnetic susceptibility, UV-Vis., P-XRD, TGA, etc., and were screened for biological activities.

Result

Synthesised azo-Schiff base ligand and its metal complexes were evaluated for their antimicrobial, antidiabetic as well as anticáncer activities against various bacteria and fungi and MCF-7 breast cancer cell line, respectively.

Conclusion

From the findings of various results, we can conclude that the synthesized metal complexes exhibit higher biological activities than the azo-Schiff base ligand.

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2024-11-05
2025-06-26

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Synthesis, Characterization, and Anticancer, Antidiabetic, and Antimicrobial Activities of Azo-Schiff Base Ligand with ONO Donor Atom and its Transition Metal Complexes
Bentham Science Publishers ; https://doi.org/10.2174/0122113525343891240925093331
/content/journals/aia/10.2174/0122113525343891240925093331
/content/journals/aia/10.2174/0122113525343891240925093331
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  • Article Type:     Review Article
Keywords: Antibacterial ; Antifungal ; Azo-aldehyde ; Bromosalicylaldehyde alpha-amylase ; Coordination

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