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image of Exploring the Therapeutic Potential of Benzimidazole Hybrids as Antimicrobial Agents: An In-Depth Analysis

Abstract

Background

Heterocyclic compounds play an essential role in biological systems and occur widely in nature. They are fundamental in the development of pharmaceuticals aimed at combating microbial infections and other” with “with the potential biological activities. Pharmacological evaluations have demonstrated their efficacy against diverse bacterial strains. This study investigates the antimicrobial properties of various benzimidazole hybrids. The findings highlight the significant influence of substituting nitrogenous scaffolds with various heteroatoms on the potential development of new antimicrobial agents.

Objective

This review article is expected to make a substantial contribution to the advancement of antibacterial medications. The research's goal is to improve the efficacy of combating bacterial infections by utilizing the potent properties of benzimidazole-based hybrid scaffolds. In the end, this will aid in reducing the global incidence of this contagious illness.

Methods

Several nitrogen-containing heterocyclic compounds display substantial potential as antibacterial agents. These compounds possess fused benzene and imidazole nuclei. These nuclei could change the number of electrons they have, which in turn affects their physiochemical characteristics. The versatility of drugs arises from their capacity to interact with receptors in various modalities, which is a key factor in drug pharmacological screening. Benzimidazole-based hybrids have demonstrated a wide range of pharma cological effects, including antibacterial, anti-HIV, anticancer, antimalarial, antiviral, an tifungal, antioxidant, anti-inflammatory, and anti-tubercular activities.

Results

Pyrazole, imidazole, oxazole, thiazole, indole, and benzimidazole are examples of compounds that include nitrogen species. These nitrogen-containing compounds engage in metabolic interactions with other molecules within the cell. Nevertheless, an overabundance of reactive nitrogen species can cause cytotoxicity, causing harm to vital biological macromolecules. But benzimidazole is traditionally the most effective, with a wide range of important qualities, including antibacterial, anti-HIV, anticancer, antimalarial, antiviral, antifungal, antioxidant, anti-inflammatory, and anti-tubercular activities.

Conclusion

This study focuses on the efficacy of novel benzimidazole-based hybrid scaffolds in inhibiting microbial growth. The study primarily focuses on recent studies carried out from 2009 to 2024. The study highlights the effectiveness of different benzimidazole-based hybrids using minimum inhibitory concentration (MIC) values. More in-depth studies also show that adding electron-withdrawing groups (EWGs) to the nitrogenous framework might make them more effective. Further research is necessary to design strong, least-toxic benzimidazole-based hybrids that can either kill or inhibit multidrug-resistant (MDR) bacteria.

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2025-01-23
2025-04-22

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Exploring the Therapeutic Potential of Benzimidazole Hybrids as Antimicrobial Agents: An In-Depth Analysis
Bentham Science Publishers ; https://doi.org/10.2174/0122113525350256250107073402
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  • Article Type:     Review Article
Keywords: electron-withdrawing ; benzimidazole ; nitrogenous ; multidrug-resistant ; Antimicrobial ; structure-activity

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