The International Journal of Gastroenterology and Hepatology Diseases - Volume 3, Issue 1, 2024

Herbal medications hold a dominant position in the pharmaceutical sector due to their well-established therapeutic effects and extremely low negative effects. Besides, herbal remedies are easily available and highly economical. However, to circumvent the issue of poor bioavailability, the combinatorial strategy of incorporating herbal medicines and nanotechnology is useful. The phytoconstituents molded in novel nanocarr Read More

BackgroundIndividuals with high body mass index (BMI) are at risk for chronic liver disease. Liver biopsy is a gold standard for the diagnosis of liver disease, as well as for determining the NAFLD activity score and fibrosis stage. Blood alanine aminotransferase (ALT) can support the presence of steatohepatitis, while the non-alcoholic fatty liver disease (NAFLD) fibrosis score (using clinical features and blood testing) may predict fi Read More

Background and ObjectivesThe COVID-19 pandemic, primarily affecting the respiratory system, has raised questions about its impact on the gastrointestinal (GI) system and liver. Current literature highlights a knowledge gap in understanding the intricate effects of COVID-19 on these organs. This study aims to investigate gastrointestinal and liver histopathology in confirmed SARS-CoV-2 patients.MethodologyA retrospe Read More

The gut microbiota plays a key role in human health. Dominated by the phyla Firmicutes and Bacteroidetes, its composition is highly individualized and influenced by diet, age, genetics, and the environment. The gut-liver axis highlights the bidirectional relationship between the gut and the liver, impacting metabolic homeostasis and immune regulation. Gut dysbiosis, an imbalance in the gut microflora, contributes to liver disease Read More

BackgroundChilaiditi syndrome is a situation with a structural impingement of the colon on the liver, leading to an elevated hemidiaphragm in the X-ray along with a gas-like appearance in the right hemithorax. It is generally a benign disease that is managed conservatively upon diagnosis. Rarely, it can be a cause of intestinal obstruction. Chilaiditi syndrome was originally named after Demetrius Chilaiditi, the Greek radiologi Read More

Metabolic-dysfunction-associated steatotic liver disease (MASLD), previously referred to as nonalcoholic fatty liver disease (NAFLD), affecting approximately 30% of the global population. Projections suggest that MASLD incidence may rise by up to 56% over the next decade. MASLD has become the fastest-growing cause of hepatocellular carcinoma (HCC) in the USA, France, UK, and other regions worldwide. The prevale Read More

Colon cancer is a major global health concern characterized by complex interactions of genetic, environmental, and lifestyle factors. The “hallmarks of cancer” encompass various distinctions between cancerous and normal tissues, including vascular characteristics, making it a possible target for medication administration with specificity. The tumor microenvironment in colon cancer is a dynamic ecosystem com Read More

IntroductionPantoprazole is a very suitable drug for the treatment of numerous acid-related conditions in humans and mammals. Owing to its short half-life (0.9 - 1.9 h), it is ideal for sustained release formulation.MethodsThis study was aimed at developing pantoprazole gastroretentive (GR) controlled-release tablets and to determine the effects of this formulation and processing parameters on drug release and other critical Read More

Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD), formerly known as Non-alcoholic fatty liver disease (NAFLD), is characterized by fat accumulation in the liver and is associated with obesity, insulin resistance, and metabolic syndrome. Early detection and intervention are crucial to prevent disease progression to advanced fibrosis, cirrhosis, and liver failure. Non-invasive tests like transient elastography (TE), the Fibro Read More

Gastrointestinal (GI) disorders encompassing conditions such as gastritis, peptic ulcers, and inflammatory bowel disorders are major global health concerns affecting millions worldwide. Conventional treatment options often come with undesirable side effects, prompting the search for alternative therapies. The herb's influence on digestive processes, mucosal protection, and modulation of gut microbiota shed light on Read More

Hepatic encephalopathy is a neurological condition that affects people who have an insufficient liver function. However, its pathophysiology is yet unclear. For hepatic encephalopathy, pharmacotherapy is the primary treatment choice. Lowering ammonia levels, enhancing neurotransmitter signal transduction, and modifying gut microbiota, tackles the pathophysiology of hepatic encephalopathy. The intestinal microbiota of li Read More

BackgroundCholedocholithiasis is defined as the presence of calculus in the biliary tract, and is one of the main complications of cholelithiasis. Its prevalence among the Mexican population is 14%.ObjectiveTo determine the validity of predictors of choledocholithiasis in patients attending the Hospital Agustin O’Horan from January 2019 to December 2020.MethodsThis was an observational, analytical, and retrospective study. It Read More

Campylobacteriosis is a foodborne disease caused by Campylobacter, which is one of the leading causative agents of bacterial gastrointestinal diseases in developed and developing countries. According to WHO, Campylobacter species infects a hundred million people yearly. The bacterium is thermotolerant, cytochrome oxidase-positive, spiral-shaped, gram-negative, and microaerophilic, by exhibiting corkscrew motility it p Read More

The gut is the most accommodating environment in the human body for bacteria. The microbial community there is both dense and varied. The gut microbe forms an axis with the human liver, according to the theory of liver disease causation. The portal vein, systemic circulation, and biliary tract all provide bidirectional connections between the liver and the intestines. The liver secretes bile acid and a wide variety of bioactiv Read More