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Volume 3, Issue 1
  • ISSN: 2666-2906
  • E-ISSN: 2666-2914

Abstract

Background and Objectives

The COVID-19 pandemic, primarily affecting the respiratory system, has raised questions about its impact on the gastrointestinal (GI) system and liver. Current literature highlights a knowledge gap in understanding the intricate effects of COVID-19 on these organs. This study aims to investigate gastrointestinal and liver histopathology in confirmed SARS-CoV-2 patients.

Methodology

A retrospective study was conducted in 2022, examining pathology slides from 37 COVID-19 patients at Namazi and Abu-Ali Sina hospitals in Shiraz, Iran. The sample population comprised all of the cases (37 patients) with confirmed COVID-19 and any type of GI pathology sample for histopathology during the study period. Data included demographics, comorbidities, symptoms, and pathology findings.

Results

The study revealed a diverse comorbidity landscape, with 45.9% having no comorbidities. Gastritis was prevalent (54.1%), accompanied by ulceration (8.1%) and mucosal edema (21.6%). Among the patients studied, four underwent liver biopsies. The pathological findings from these biopsies included cirrhosis, autoimmune hepatitis, chronic inflammation and fibrosis, and microvesicular glycogenosis.

Conclusion

Gastrointestinal and liver histopathologies in COVID-19 patients were heterogeneous and nonspecific, possibly influenced by comorbidities. Given the potential of SARS-CoV-2 to infect the enterocytes and hepatocytes and the possible involvement of other factors, such as drugs, ischemia, or preexisting conditions, in the gastrointestinal and liver injury of COVID-19 patients, more research is warranted to better understand the pathogenesis and clinical implications of these findings.

© 2024 Bentham Science Publishers
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2024-10-02
2025-01-31

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Gastrointestinal and Liver Histopathology in Confirmed SARS-CoV-2 Patients: A Case Series
Int J Gastroenterol Hepatol Dis 3, E26662906302968 (2024); https://doi.org/10.2174/0126662906302968240826093950
/content/journals/ijghd/10.2174/0126662906302968240826093950
/content/journals/ijghd/10.2174/0126662906302968240826093950
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  • Article Type:     Research Article
Keyword(s): comorbidities; COVID-19; gastritis; gastrointestinal pathology; Helicobacter pylori; liver pathology

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