Skip to content
2000
  1. Home
  2. A-Z Publications
  3. The International Journal of Gastroenterology and Hepatology Diseases
  4. Volume 3, Issue 1
  5. Article
Volume 3, Issue 1
  • ISSN: 2666-2906
  • E-ISSN: 2666-2914

Abstract

Gastrointestinal (GI) disorders encompassing conditions such as gastritis, peptic ulcers, and inflammatory bowel disorders are major global health concerns affecting millions worldwide. Conventional treatment options often come with undesirable side effects, prompting the search for alternative therapies. The herb's influence on digestive processes, mucosal protection, and modulation of gut microbiota shed light on maintaining potential GI health. (Gentianaceae), commonly known as '', is a traditional medicinal herb that has been used for centuries in various cultures for its therapeutic benefits, particularly for GI ailments. Furthermore, this review highlights several scientific studies and clinical trials that support the traditional uses of in treating GI disorders. In conclusion, could be beneficial as a natural remedy with promising therapeutic potential for managing GI disorders. However, there are still some scientific gaps, such as the identification of bioactive compounds, the structure-activity relationship, the mechanistic action of isolated bioactive compounds, the development of effective analytical methods for comprehensive quality control, and safety profiles, that need to be addressed. Understanding its molecular mechanisms and conducting further clinical trials will contribute to establishing as a valuable addition to the armamentarium of natural therapies for GI health.

© 2024 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/ijghd/10.2174/0126662906301632240528055034
2024-06-24
2025-01-31

  • From This Site

    /content/journals/ijghd/10.2174/0126662906301632240528055034
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. PaboluS. DudekulaA. PitchumoniC.S. Gastrointestinal Manifestations of Non-GI Disorders. Geriatric Gastroenterology.ChamSpringer202121172166
     [Google Scholar]
  2. JabłońskaB. MrowiecS. Gastrointestinal disease: New diagnostic and therapeutic approaches.Biomedicines2023115142010.3390/biomedicines11051420 37239091
     [Google Scholar]
  3. LeeK.S. KimE.S. Explainable artificial intelligence in the early diagnosis of gastrointestinal disease.Diagnostics20221211274010.3390/diagnostics12112740 36359583
     [Google Scholar]
  4. Greenwood-Van MeerveldB. JohnsonA.C. GrundyD. Gastrointestinal physiology and function.Handb. Exp. Pharmacol.201723911610.1007/164_2016_118
     [Google Scholar]
  5. DrossmanD.A. TackJ. FordA.C. SzigethyE. TörnblomH. Van OudenhoveL. Neuromodulators for functional gastrointestinal disorders (disorders of gut-brain interaction): A Rome foundation working team report.Gastroenterology2018154411401171.e110.1053/j.gastro.2017.11.279 29274869
     [Google Scholar]
  6. MilivojevicV. MilosavljevicT. Burden of gastroduodenal diseases from the global perspective.Curr. Treat. Options Gastroenterol.202018114815710.1007/s11938‑020‑00277‑z 31993967
     [Google Scholar]
  7. AnanthakrishnanA.N. Xavier, RJ Gastrointestinal diseases. Hunter's Tropical Medicine and Emerging Infectious Diseases.Elsevier2020162610.1016/B978‑0‑323‑55512‑8.00003‑X
     [Google Scholar]
  8. EslickG.D. Gastrointestinal symptoms and obesity: A meta‐analysis.Obes. Rev.201213546947910.1111/j.1467‑789X.2011.00969.x 22188520
     [Google Scholar]
  9. GroverM. FarrugiaG. StanghelliniV. Gastroparesis: A turning point in understanding and treatment.Gut201968122238225010.1136/gutjnl‑2019‑318712 31563877
     [Google Scholar]
  10. ThomsonA.B.R. SauveM.D. KassamN. KamitakaharaH. Safety of the long-term use of proton pump inhibitors.World J. Gastroenterol.201016192323233010.3748/wjg.v16.i19.2323 20480516
     [Google Scholar]
  11. PasrichaP.J. Treatment of disorders of bowel motility and water flux; antiemetics; agents used in biliary and pancreatic disease. Goodman & Gilmans The Pharmacological Basis of Therapeutics.11th edNew YorkMcGraw-Hill20069831008
     [Google Scholar]
  12. EkorM. The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety.Front. Pharmacol.2014417710.3389/fphar.2013.00177 24454289
     [Google Scholar]
  13. RahimiR. AbdollahiM. Herbal medicines for the management of irritable bowel syndrome: A comprehensive review.World J. Gastroenterol.201218758960010.3748/wjg.v18.i7.589 22363129
     [Google Scholar]
  14. SedaiC.P. Altitudinal variation of the bitter principle of Swertia chirayita and its standardization.Master's thesis.2015
     [Google Scholar]
  15. PatilK. DhandeS. KadamV. Therapeutic Swertia chirata: An overview.J. Pharmacogn. Phytochem.201354199207
     [Google Scholar]
  16. ChandraS. KumarV. BandopadhyayR. SharmaM.M. SEM and elemental studies of Swertia chirayita: A critically endangered medicinal herb of temperate Himalayas.Curr. Trends Biotechnol. Pharm.201263381388
     [Google Scholar]
  17. KhanA. RahimA. IqbalZ. GilaniA.H. Insights into mechanisms underlying the gut and airways modulatory effects of Swertia chirata.J. Nat. Med.201266114014810.1007/s11418‑011‑0566‑2 21792726
     [Google Scholar]
  18. BrahmachariG. MondalS. GangopadhyayA. GoraiD. MukhopadhyayB. SahaS. BrahmachariA.K. Swertia (Gentianaceae): Chemical and pharmacological aspects.Chem. Biodivers.20041111627165110.1002/cbdv.200490123 17191805
     [Google Scholar]
  19. DukeJ.A. Database of phytochemical constituents of GRAS herbs and other economic plants.CRC Press1992
     [Google Scholar]
  20. BhattacharyaS.K. ReddyP.K.S.P. GhosalS. SinghA.K. SharmaP.V. Chemical constituents of Gentianaceae XIX: CNS-depressant effects of swertiamarin.J. Pharm. Sci.197665101547154910.1002/jps.2600651037 988172
     [Google Scholar]
  21. NiihoY. YamazakiT. NakajimaY. YamamotoT. AndoH. HiraiY. ToriizukaK. IdaY. Gastroprotective effects of bitter principles isolated from Gentian root and Swertia herb on experimentally-induced gastric lesions in rats.J. Nat. Med.2006601828810.1007/s11418‑005‑0014‑2
     [Google Scholar]
  22. JoshiP. DhawanV. Swertia chirayita: An overview.Curr. Sci.2005635640
     [Google Scholar]
  23. StruweL. PringleJ.S. “Gentianae”, nom. cons. Flowering Plants. Eudicots: Apiales.Gentianales17892018453503
     [Google Scholar]
  24. LiJ. XuY. ZhaoL. Swertia hongquanii, a new species of Gentianaceae from Mt. Wuling, southern China.PhytoKeys201913211010.3897/phytokeys.132.37009 31579138
     [Google Scholar]
  25. AnonI. The Wealth of India: Raw Materials. Publication and Information Directorate.New DelhiCSIR19827881
     [Google Scholar]
  26. DukeJ.A. Handbook of medicinal herbs.Boca RatonCRC Press200210.1201/9781420040463
     [Google Scholar]
  27. KumarV. Van StadenJ. A review of Swertia chirayita (Gentianaceae) as a traditional medicinal plant.Front. Pharmacol.2016630810.3389/fphar.2015.00308 26793105
     [Google Scholar]
  28. AleemA. KabirH. Review on Swertia chirata as traditional uses to its phytochemistry and phrmacological activity.J. Drug Deliv. Ther.201885-s737810.22270/jddt.v8i5‑s.1957
     [Google Scholar]
  29. ŚāstrīK. ChaturvediG. Caraka-saṁhitāChaukhambha Bharati AcademyVaranasi2011721
     [Google Scholar]
  30. ŚāstrīK. ChaturvediG. Caraka-saṁhitāChaukhambha Bharati AcademyVaranasi201114185186
     [Google Scholar]
  31. ŚāstrīK. ChaturvediG. Caraka-saṁhitāChaukhambha Bharati AcademyVaranasi201115137140
     [Google Scholar]
  32. ŚāstrīK. ChaturvediG. Caraka-saṁhitāChaukhambha Bharati AcademyVaranasi2011195255
     [Google Scholar]
  33. ŚāstrīK. ChaturvediG. Caraka-saṁhitāChaukhambha Bharati AcademyVaranasi20112195
     [Google Scholar]
  34. TripathiB. Aṣṭāñgahṛayam.Chaukhambha Sanskrit PratishthanDelhi20118102
     [Google Scholar]
  35. SharmaP. Vaidyajīvanam2013135
     [Google Scholar]
  36. SwatiK. BhattV. SendriN. BhattP. BhandariP. Swertia chirayita: A comprehensive review on traditional uses, phytochemistry, quality assessment and pharmacology.J. Ethnopharmacol.202330011571410.1016/j.jep.2022.115714 36113678
     [Google Scholar]
  37. SelvamathyS.M. GeethaA. SaranyaP. Gastroprotective effect of Swertia chirayita-a study with ulcer induced rats.Pharmacologyonline20101332355
     [Google Scholar]
  38. RafatullahS. TariqM. MossaJ.S. al-YahyaM.A. al-SaidM.S. AgeelA.M. Protective effect of Swertia chirata against indomethacin and other ulcerogenic agent-induced gastric ulcers.Drugs Exp. Clin. Res.19931926973 8223145
     [Google Scholar]
  39. PantN. JainD.C. BhakuniR.S. ChemInform abstract: Phytochemicals from genus swertia and their biological activities.ChemInform2001323
     [Google Scholar]
  40. MohiuddinA. Indigenous plants as sources of pharmacological interests.J. Glob. Biosci.20198159005915
     [Google Scholar]
  41. LadH. BhatnagarD. Amelioration of oxidative and inflammatory changes by Swertia chirayita leaves in experimental arthritis.Inflammopharmacology201624636337510.1007/s10787‑016‑0290‑3 27738917
     [Google Scholar]
  42. De PontiF. MalageladaJ.R. Functional gut disorders: From motility to sensitivity disorders. A review of current and investigational drugs for their management.Pharmacol. Ther.1998801498810.1016/S0163‑7258(98)00021‑7 9804054
     [Google Scholar]
  43. SinghD. ChoW.C. UpadhyayG. Drug-induced liver toxicity and prevention by herbal antioxidants: An overview.Front. Physiol.2016636310.3389/fphys.2015.00363 26858648
     [Google Scholar]
/content/journals/ijghd/10.2174/0126662906301632240528055034
Loading
Swertia chirayita (Roxb.) H. Karst.: A Magnificent Natural Remedy for the Management of Gastrointestinal Disorders
Int J Gastroenterol Hepatol Dis 3, E240624231285 (2024); https://doi.org/10.2174/0126662906301632240528055034
/content/journals/ijghd/10.2174/0126662906301632240528055034
/content/journals/ijghd/10.2174/0126662906301632240528055034
Loading

Data & Media loading...


  • Article Type:     Review Article
Keyword(s): Gastrointestinal disorders; nausea; pharmacology; phytoconstituents; Swertia chirayita; taxonomy

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test