Drug Delivery Letters - Volume 12, Issue 3, 2022

Background: Psoriasis is a long-term chronic inflammatory, autoimmune and reoccurring skin condition. About 2% to 5% of the world's population is impacted by psoriasis. People affected by psoriasis are more prone to develop other health conditions including psoriatic arthritis, anxiety, depression and cardiovascular disorders. Long-term use of several synthetic medications used for their management has been showing Read More

Periodontitis is a serious gum infection associated with inflammation of the periodontium around the teeth. Based on the etiology and pathogenesis, periodontitis has several conventional treatment strategies. Treatment with antibiotics and antimicrobials is the most common therapy. However, the development of drug resistance and the manifestation of side effects make conventional strategies ineffective. In recent decades, lo Read More

Background: Amitriptyline hydrochloride is a Tricyclic Antidepressant (TCA) belonging to BCS class I exhibiting only 30-60% bioavailability and often coupled with poor patient compliance. The primary objective was to develop a formulation with commercial viability and reduced dosing frequency in order to promote adherence of depressed patients to the treatment regime. The study also focused on reducing the dose of amitripty Read More

Aim: The present study developed an oral in-situ gel containing the leaf extract of Taraxacum officinale (T.O.) using an experimental design. Background: Peptic ulcer disease was an epidemic in the 19th and early 20th centuries. The application of herbal drugs for peptic diseases is an attractive area for research and implementation as compared to the allopathic system in the recent era. From the number of plants, th Read More

Background: Memory disorders require a steady-state balance of choline and cytidine. Citicoline is prescribed as an exogenous source of choline and cytidine. Objective: The present study proposes a mucoadhesive multiparticulate sustained delivery of citicoline as a supportive control for memory loss. Methods: The formulation of citicoline sodium microparticles was done by ionotropic gelation method using alginate and h Read More