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- Volume 19, Issue 25, 2013
Current Pharmaceutical Design - Volume 19, Issue 25, 2013
Volume 19, Issue 25, 2013
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Modulation of Individual Susceptibility to the No-Reflow Phenomenon after Acute Myocardial Infarction
More LessCoronary reperfusion using primary percutaneous coronary intervention (PCI) dramatically reduces morbidity and mortality among patients with acute myocardial infarction (AMI). Nevertheless, inadequate myocardial perfusion, known as the “no-reflow” phenomenon, is observed in approximately 15% of patients and is associated with poor outcomes. No-reflow is caused not only by mechanical occlusion of the micro Read More
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Protecting the Heart: Biological Targets and Clinical Strategies
Authors: Alberto R. D. Caterina, Florim Cuculi, Adrian P. Banning and Rajesh K. KharbandaThe pathophysiology of myocardial damage in the setting of ischemic cardiomyopathy is complicated by the fact that the process of restoring blood flow to the ischemic cardiomyocytes can itself induce injury to the myocardium. This phenomenon, termed reperfusion injury, reduces the benefits of vessel recanalization and contributes to the damage initiated by occlusion. The interest on techniques aiming at protecting the heart f Read More
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Cardioprotection Techniques: Preconditioning, Postconditioning and Remote Con-ditioning (Basic Science)
More LessIschemic heart disease (IHD) is the leading cause of death and disability worldwide. The major pathological consequences of IHD arise from the detrimental effects of acute ischemia-reperfusion injury (IRI) on the myocardium. Therefore, in order to improve clinical outcomes in patients with IHD, novel therapeutic strategies are required to protect the myocardium from acute IRI and preserve cardiac function (cardioprotectio Read More
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No-reflow: Incidence and Detection in The Cath-Lab
The primary goal in patients with ST-elevation myocardial infarction (STEMI) is the restoration of myocardial tissue-level perfusion. In a variable proportion of patients with STEMI, however, microcirculatory impairment may persist after epicardial coronary artery recanalization. This phenomenon is known as “myocardial no-reflow”. Of note, no-reflow is associated with a worse prognosis both at short- and long-term f Read More
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Mechanisms, Prevention and Treatment of Distal Embolization
Authors: Italo Porto, Giovanni Luigi D. Maria, Maurizio Pieroni, Leonardo Bolognese and Filippo CreaDistal embolization (DE) can be either spontaneous or iatrogenic, occurring during percutaneous coronary intervention (PCI). The nature, composition and biochemical properties of embolized material differ according to the setting in which DE occurs: acute coronary syndromes (ACS) or stable coronary artery disease (CAD). DE occurrence is related to increased cardiac biomarkers, negative left ventricular remodeling Read More
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Therapy Against Ischemic Injury
Authors: Giacinta Guarini, Alda Huqi, Paola Capozza, Doralisa Morrone, Francesca Donati and Mario MarzilliThe advent of reperfusion therapy constituted a historical change for the management of myocardial infarction (MI) patients. However, shortly after, experimental models recognized an intrinsic damage, related to reperfusion itself, which was termed as ischemiareperfusion injury (IRI). Clinical studies attribute IRI a significant burden of morbidity and mortality observed in patients undergoing successful epicardial reperfu Read More
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Identification and Usage of Fluorescent Probes as Nanoparticle Contrast Agents in Detecting Cancer
Authors: Manikanta S. Murahari and Mayur C. YergeriAs advancements in the field of nanoparticle imaging science are made, one of the first benefits will be in open and endoscopic conditions. There is considerable evidence indicating that the use of injected contrast agents can improve the detection of tumor margins and small metastases. New and innovative targeting and contrast agents including small molecules, antibodies and nanoparticles have to be developed for a broad Read More
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The Biology of the Peroxisome Proliferator-activated Receptor System in the Female Reproductive Tract
Authors: Leandro M. Velez, Giselle Adriana Abruzzese and Alicia Beatriz MottaFuel sensors such as glucose, insulin or leptin, are known to be directly involved in the regulation of fertility at each level of the hypothalamic-pituitary-gonadal axis. The discovery of the peroxisome proliferator-activated receptor (PPAR) family of transcription factors has revealed the link between lipid/glucose availability and long-term metabolic adaptation. By binding to specific regions of DNA in heterodimers with the reti Read More
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Probes for Non-invasive Matrix Metalloproteinase-targeted Imaging with PET and SPECT
Dysregulation of matrix metalloproteinase (MMP) activity can lead to a wide range of disease states such as atherosclerosis, inflammation or cancer. The ability to image MMP activity non-invasively in vivo, by radiolabelled synthetic inhibitors, would allow the characterization of atherosclerotic plaques, inflammatory lesions or tumors. Here we present an overview of radiolabelled MMP inhibitors (MMPIs) and MMP Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
- Issue 42
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- Issue 1
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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