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- Volume 19, Issue 41, 2013
Current Pharmaceutical Design - Volume 19, Issue 41, 2013
Volume 19, Issue 41, 2013
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Physical and Chemical Stimuli-Responsive Drug Delivery Systems: Targeted Delivery and Main Routes of Administration
Authors: Joana R. Lopes, Gory Santos, Pedro Barata, Rita Oliveira and Carla M. LopesIn the area of drug delivery, novel tools and technological approaches have captured the attention of researchers in order to improve the performance of conventional therapeutics and patient compliance to pharmacological therapy. Stimuli-responsive drug delivery systems (DDS) appear as a promising approach to control and target drug delivery. When these DDS are administered, the drug release is activated an Read More
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Current Progresses on Nanodelivery Systems for the Treatment of Neuropsychiatric Diseases: Alzheimer’s and Schizophrenia
Authors: A.C. Silva, E. Gonzalez-Mira, J.M. S. Lobo and M.H. AmaralCurrently Alzheimer's disease and schizophrenia are both well-established neuropsychiatric diseases. Nonetheless, the treatment of these disorders is not unanimous and fully effective. As a consequence, several approaches have been studied to improve patient’s conditions. In this context, the development of new drug nanodelivery systems to increase drug bioavailability and reduce adverse effects has been claimed as a good Read More
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In Vivo Anticancer Activity of Methotrexate-loaded Layered Double Hydroxide Nanoparticles
Authors: Soo-Jin Choi, Jae-Min Oh, Hae-Eun Chung, Seung-Hee Hong, In-Hoo Kim and Jin-Ho ChoyA methotrexate (MTX)-loaded layered double hydroxide (LDH) nanoparticle system was synthesized by intercalating MTX into the interlayer spaces of LDH. In vivo pharmacokinetic study demonstrated that the MTX-LDH hybrid had similar kinetic behaviors as free MTX, showing a rapid decline in the plasma MTX level, with characteristics of a biexponential function. However, the hybrid system remarkably suppressed tumor growt Read More
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Smart Stimuli Sensitive Nanogels in Cancer Drug Delivery and Imaging: A Review
Authors: S. Maya, Bruno Sarmento, Amrita Nair, N. S. Rejinold, Shantikumar V. Nair and R. JayakumarNanogels are nanosized hydrogel particles formed by physical or chemical cross-linked polymer networks. The advantageous properties of nanogels related to the ability of retaining considerable amount of water, the biocompatibility of the polymers used, the ability to encapsulate and protect a large quantity of payload drugs within the nanogel matrix, the high stability in aqueous media, their stimuli responsively behavi Read More
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Innovative Formulations for the Controlled and Site-specific Delivery of Antiinflammatory Drugs
Authors: L. Serpe, R. Canaparo, F. Foglietta and G.P. ZaraPharmaceutical technology has introduced a promising pathway in the future of medicine in particular nanotechnological innovations have provided the opportunity to design and develop efficient drug delivery systems able to target and treat several diseases, including those mediated by inflammation. The engineering of drug delivery systems can be used to target tissues involved in the pathology under treatment, to avoi Read More
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Nanodelivery Systems for Improved Topical Antimicrobial Therapy
Authors: Purusotam Basnet and Natasa Skalko-BasnetComplications related to infectious diseases have significantly reduced, specially in the developed countries, due to the availability and use of a wide variety of antibiotics and antimicrobial agents, however, anti-infective therapy is still not considered to be optimal. Excessive use of antibiotics and antimicrobial agents increased the number of drug resistant pathogens, leading to urgent need for advanced therapeutic strategies Read More
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Drug Delivery Systems for the Treatment of Diabetes Mellitus: State of the Art
Authors: Gary G. Adams and Stephen E. HardingArguably one of the greatest medical advancements in the 20th Century was the discovery of insulin. Physiologically, insulin is a potent hypoglycaemic agent, which is vital in order for plasma glucose levels to be maintained within the normal range of 4- 7mmol/L. Various attempts have been made in the production, purification, formulation and methods of delivery of insulin. Despite alternative routes being investig Read More
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Development and Evaluation of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and Polycaprolactone Microparticles of Nimodipine
Polymeric microparticles containing the calcium channel blocker nimodipine were successfully obtained through simple emulsion/ organic solvent evaporating method. The extended release formulations, composed by the polymers poly(3-hydroxybutyrate-co-3- hydroxyvalerate) (PHBV) and polycaprolactone (PCL), were submitted to characterization through X-ray powder diffraction (XRPD), scanning electron microscopy (SE Read More
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Delivery Systems of Opioid Analgesics for Pain Relief: A Review
Authors: Wojciech Leppert, Malgorzata Krajnik and Jerzy WordliczekChronic pain is usually treated with pharmacological measures using opioids alone or in combination with adjuvant analgesics that play an important role in the treatment of pain not fully responsive to opioids administered alone, especially in neuropathic, bone and visceral colicky pain. The important part of the chronic pain treatment is the appropriate use of non-pharmacological measures along with psychosocial and s Read More
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In Vivo Gastroprotective Effect of Nanoparticles: Influence of Chemical Composition and Volume Fraction
In nanomedicine, different nanomaterials and nanoparticles have been proposed as therapeutic agents or adjuvants, as well as diagnosis devices. Considering that the principal cause of the ulcerations is the imbalance among the gastric juice secretion and the protection provided by the mucosal barrier and the neutralization of the gastric acid, as well as that nanoparticles are able to accumulate in the gastro-intestinal tis Read More
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Needle-free Gene Delivery Through the Skin: An Overview of Recent Strategies
Authors: Mahmoud Elsabahy and Marianna FoldvariTopical administration is attractive and non-invasive gene delivery approach. It is simple and allows repeated administration. In addition, the skin is active immune surveillance site. Topical gene therapy, although promising for treatment of cancer, dermatological disorders, vaccination and autoimmune disease, has not progressed yet to clinical trials. The inability of nucleic acids to survive the extraand intracellular environm Read More
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Nanotechnological Strategies for the Treatment of Neglected Diseases
Neglected diseases are prevalent in less developed countries and are associated with high levels of mortality and/or morbidity. The drugs used in clinical practice are toxic, reducing patient compliance, and generally do not result in a cure, and there has also been a surge in drug resistance. Additionally, a major challenge in drug treatment lies in reaching the intracellular sites infected by parasites. The development of nanot Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
- Issue 42
- Issue 41
- Issue 40
- Issue 39
- Issue 38
- Issue 37
- Issue 36
- Issue 35
- Issue 34
- Issue 33
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 28
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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