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- Volume 19, Issue 37, 2013
Current Pharmaceutical Design - Volume 19, Issue 37, 2013
Volume 19, Issue 37, 2013
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Mechanisms for Targeted Delivery of Nanoparticles in Cancer
Authors: Jaymes R. Beech, Soo J. Shin, Jeffrey A. Smith and Kimberly A. KellyWith the evolution of the “omics” era, our molecular understanding of cancer has exponentially increased, leading to the development of the concept of personalized medicine. Nanoparticle technology has emerged as a way to combine cancer specific targeting with multifunctionality, such as imaging and therapy, leading to advantages over conventional small molecule based approaches. In this review, we discuss the Read More
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Recent Advances in Superparamagnetic Iron Oxide Nanoparticles for Cellular Imaging and Targeted Therapy Research
Authors: Yi-Xiang J. Wang, Shouhu Xuan, Marc Port and Jean-Marc IdeeAdvances of nanotechnology have led to the development of nanomaterials with both potential diagnostic and therapeutic applications. Among them, superparamagnetic iron oxide (SPIO) nanoparticles have received particular attention. Over the past decade, various SPIOs with unique physicochemical and biological properties have been designed by modifying the particle structure, size and coating. This article reviews Read More
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Design and In vitro Validation of Multivalent Dendrimer Methotrexates as a Folate-targeting Anticancer Therapeutic
Design of cancer-targeting nanotherapeutics relies on a pair of two functionally orthogonal molecules, one serving as a cancer cell-specific targeting ligand, and the other as a therapeutic cytotoxic agent. The present study investigates the validity of an alternative simplified strategy where a dual-acting molecule which bears both targeting and cytotoxic activity is conjugated to the nanoparticle as cancer-targeting na Read More
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Interactions of Iron Oxide Nanoparticles with the Immune System: Challenges and Opportunities for their Use in Nano-oncology
Authors: Dana C. Baiu, Christopher S. Brazel, Yuping Bao and Mario OttoIron oxide (IO) nanoparticles hold great promise as diagnostic and therapeutic agents in oncology. Their intrinsic physical properties make IO nanoparticles particularly interesting for simultaneous drug delivery, molecular imaging, and applications such as localized hyperthermia. Multiple non-targeted IO nanoparticle preparations have entered clinical trials, but more exciting, new tumortargeted IO nanoparticle preparatio Read More
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Nanomaterials for Photohyperthermia: A Review
Authors: Jonathan Fang and Yu-Chie ChenThe unique properties of nanomaterials have propelled the field of nanomedicine. Nanomaterials have been used as drug delivery, imaging, and photothermal agents for diagnosis and therapy of diseases. Recently, photohyperthermia has attracted great interest from researchers and is actively being investigated as an alternative method of therapy for cancer and even bacteria. Photohyperthermia, or photothermal ther Read More
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Targeted Drug Delivery Across the Blood Brain Barrier in Alzheimer's Disease
By Sandra RochaThe discovery of drugs for Alzheimer's disease (AD) therapy that can also permeate the blood brain barrier (BBB) is very difficult owing to its specificity and restrictive nature. The BBB disruption or the administration of the drug directly into the brain is not an option due to toxic effects and low diffusion of the therapeutic molecule in the brain parenchyma. A promising approach for drug systemic delivery to the central nervo Read More
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Effect of Liposomes on the Absorption of Water-soluble Active Pharmaceutical Ingredients via Oral Administration
Authors: Zhijun Yang, Aiping Lu, Blenda Chi Kwan Wong, Xiaoyu Chen, Zhaoxiang Bian, Zhongzhen Zhao, Wenhua Huang, Ge Zhang, Hubiao Chen and Min XuThe objective of this study was to investigate the effect of liposomes on the absorption of water-soluble active pharmaceutical ingredients. Salbutamol sulfate (SBS) has been widely used for treatment of bronchospasm in conditions such as asthma. Using SBS as the model drug in this study, we developed SBS-loaded liposomes for oral administration and explored the relationship between their bioavailability and anti-as Read More
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Combating P-glycoprotein-Mediated Multidrug Resistance Using Therapeutic Nanoparticles
More LessThe development of multidrug resistance (MDR) to chemotherapy is a major obstacle for the successful treatment of cancer. A number of mechanisms have been postulated to account for MDR in cancer. The most common and best-studied mechanism of resistance is mediated through the drug efflux protein P-glycoprotein (P-gp), which is overexpressed in drug-resistant cancer cells and is responsible for the re Read More
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Toward a Better Understanding of Pharmacokinetics of Nanomaterials
Authors: Chengke Zhang, Qiu Zhang, Yi Zhang and Bing YanNanotechnology has promising applications in biomedicine, such as in drug delivery, diagnosis, and tissue engineering. The pharmacokinetics of nanomaterials significantly affects their biological behavior in vivo, affecting their biomedical applications and potential nanotoxicity. In this review, we highlight some recent advances in the pharmacokinetic studies of representative nanomaterials. We focus on the relationships betw Read More
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Iron Oxide Nanoparticle-induced Oxidative Stress and Genotoxicity in Human Skin Epithelial and Lung Epithelial Cell Lines
Authors: Maqusood Ahamed, Hisham A. Alhadlaq, Javed Alam, M.A. Majeed Khan, Daoud Ali and Saud AlarafiIron oxide (Fe3O4) nanoparticles (IONPs) have received much attention for their utility in biomedical applications such as magnetic resonance imaging, drug delivery and hyperthermia. Recent studies reported that IONPs induced cytotoxicity in mammalian cells. However, little is known about the genotoxicity of IONPs following exposure to human cells. In this study, we investigated the cytotoxicity, oxidative stress and ge Read More
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Evaluation of the Biological Fate and the Transport Through Biological Barriers of Nanosilver in Mice
Authors: Zhe Wang, Guangbo Qu, Lina Su, Lei Wang, Zuozhi Yang, Junqiang Jiang, Sijin Liu and Guibin JiangNanosilver (nAg) is a considerably important nanomaterial due to its unique physical and chemical features and its intrinsic antimicrobial properties. Thus far, nAg has been widely applied in a variety of fields including biomedicine. Considering the safety and adverse influence, investigations into the biological fate and potential toxicity of nAg are essential for its safe and appropriate applications. In the current study, we exposed n Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
- Issue 42
- Issue 41
- Issue 40
- Issue 39
- Issue 38
- Issue 37
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- Issue 31
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- Issue 27
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- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 28
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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