Current Pharmaceutical Analysis - Volume 20, Issue 8, 2024

IntroductionCordyceps sinensis, a renowned traditional Chinese medicinal substance, contains pharmacologically beneficial compounds, including γ-aminobutyric acid (GABA), necessitating efficient analytical methods for quality assessment. This study aims to develop a rapid, cost-effective, and eco-friendly liquid chromatography-tandem mass spectrometry (LC–MS/MS) method for GABA quantification in Cordyceps sinensis and it Read More

ObjectiveThe objective of the present work is to develop and validate a novel, specific, precise, and reliable method for the estimation of Calotropis gigantea in bulk and herbal dosage form using the RP-HPLC method.MethodsRP-HPLC analysis was performed using a C18 column of dimension 150×4.6mm, 5 µ. The chromatography system comprised an Agilent 1220 Infinity II LC equipped with a VWD detector and a 1220 Infinit Read More

BackgroundThe in-vitro release test (IVRT) is a tool to measure the amount and the release rate of active pharmaceutical compounds released from topical semisolid dosage forms. The IVRT provides significant information for product performance assessment and evaluation. It is also used to assess the bioequivalence study (biowaivers) for topical semisolid products.ObjectiveThe study aims to develop and validate the IVRT Read More

BackgroundN-nitrosamines have recently been discovered in metformin hydrochloride and other generic drugs. To quantify the five N-nitrosamines in metformin hydrochloride, we devised sensitive and reliable multiple reactions monitoring mode-based GC-MS/MS technique, particularly, N-nitrosodiethy amine (NDEA), N-nitroso ethyl isopropylamine (NEIPA), N-nitrosodiisopropylamine (NDIPA), N-nitrosodipropylamine (NDPA), Read More