Current Organic Chemistry - Volume 20, Issue 28, 2016

By the developmentof new antineoplastic drugs addressed tospecific sites (key to tumor growth), targeted agents, which do not interfere with most normal cells have many advantages like fewer side effects (as personalized treatment), and prolonged survival time of cancer patients compared to conventional therapy. As current approaches in cancer therapy, drug delivery systems based on polymers (synthetic, natural or comb Read More

Background: Smart stimulus-responsive nanocarriers represent a rapidly growing class of drug-delivery systems for cancer and other diseases. Objective: The alterations of redox potential between the intracellular environment and the extracellular space have been widely utilized as a trigger for delivery of therapeutic agents by smart stimulus-responsive nanocarriers. We set out to review the scientific literature. Metho Read More

RNA interference has been developed as a powerful technology for cancer therapy by intracellular delivery of siRNA and stably silences the specific related genes. Despite rapid advances regarding the intracellular delivery technologies of siRNA, cytotoxicity, survivability, and responses still generate significant challenges for the translation of basic medicine to clinical practices. In this review, biogenesis and function of siRNA Read More

Current therapeutic strategies used in many types of cancer are confronted with the major problem of multidrug resistance (MDR) that can be acquired through several mechanisms. To overcome this limitation, new therapeutic options are being explored involving state-of-the-art technologies. In this respect, small- interfering RNA (siRNA) technology offers the possibility to block the expression of genes that are inv Read More

It is well known that over the time each species has directed a specific function of its metabolic activity for survival, development and perpetuation, towards a sustained seeking for a balance with the surrounding environment. In this respect, plants became a major point of interest for the pharmaceutical industry due to their capacity of synthetizing organic compounds with specific pharmacological activity, most of them as Read More

Functional biomaterials able to sense and respond to biotic and abiotic stimuli are currently clustered in the category of smart materials. Polymers represent the most investigated class of materials able to change different morphological, functional, architectural and biological properties as a feedback to an external inducing element. Although very useful in most industrial, biotechnological and ecological approaches, biopolym Read More

Organocatalysis is an emerging and new field towards the direction of asymmetric synthesis and has shown a tremendous growth in 21st century. As the demand for chiral pharmaceuticals and chiral organic molecules is increasing immensely, different types of organocatalysts have been developed and used from time to time. The cinchona alkaloids and amino acid proline were the first organocatalysts used in this area fol Read More

9,9-Dimethyl-9H-9-silafluorene (1) is one of the hetero-polycyclic aromatic compounds containing a silicon atom in their rings. NMR observation of the reaction of 1 with superacid at low temperature showed the quantitative formation of biphenyl. The nitration of 1 with HNO3/CH2Cl2 gave 9,9-dimethyl-2-nitro-9H-9-silafluorene in 24% yield. Friedel– Crafts alkylation with tert-BuCl/FeCl3 afforded 4,4’-di-tert-butylbiphenyl in 98% yi Read More