Current Organic Chemistry - Volume 20, Issue 21, 2016

In this review we chose to concentrate on the bibliography data from 2013 to 2015 (until February), related to the application of the Inverse Electron Demand Diels-Alder (IEDDA) reaction to the synthesis of heterocycles, as building blocks for natural products synthesis. Moreover, the application of the IEDDA reaction to the recently developed bioorthogonal ligations (in 2008), using tetrazines moieties as the diene part Read More

The hetero-Diels-Alder reaction is one of the most powerful transformations in the chemistry toolbox for the synthesis of heterocycles. In this article, the recent developments of this reaction are presented involving heterodienophiles such as imines, azenes, carbonyls, thiocarbonyls, and nitroso compounds as well as heterobutadienes such as azabutadienes, diaazabutadienes, oxabutadienes, thiabutadienes, nitrosoalkene Read More

The Diels-Alder reactions can be classified as click reactions because of their simplicity and high yields. The Diels-Alder click reactions have been used for the preparation of complex macromolecules, such as hydrogels and polymers and also for labeling of various biological targets. This review summarizes the recent application of Diels-Alder click reactions in hydrogel synthesis, polymer and material science and also me Read More

The Diels-Alder cycloaddition between a (hetero)diene and a (hetero)dienophile can be performed with metal Lewis Acids. Such activation often increases the rate of the reaction and has an influence on the observed selectivity. The most recent advances on metal promoted Diels-Alder reactions are reviewed.

Diels Alder cycloaddition is one of the most valuable reactions in organic chemistry for the building of cyclic systems. Recent advances in metabolic engineering, computational methods and chemical biology in general, have allowed designing new artificial enzymes. Apart from, metal and simple organic catalysts more complex catalytic systems based on proteins, RNA and DNA fragments have been demonstrated to be active as Read More