Current Organic Chemistry - Volume 20, Issue 8, 2016

Tubercidin represents one of the most widely recognized nucleosides isolated from natural sources. The major structural difference between adenosine and tubercidin is that one of the nitrogen atom is replaced by a C-H group in the heterocyclic base. Tubercidin was first introduced into the clinic over 40 years ago. Since then, there has been a steady interest and this review discusses the various approaches related to th Read More

Calothrixin A and B are pentacyclic alkaloids isolated from Calothrix Cyanobacteria with unique structural features containing indolo[3,2-j]phenanthridine ring system. These alkaloids possess various biological activities including growth inhibitory effects on a chloroquine-resistant strain of the malarial parasite Plasmodium falciparum and activity against human cancer cells. In this review, various synthetic approac Read More

In the recent few years, the emergence of nucleosides containing modified sugar ring or modified base moiety has gained much attention due to their enhanced biological activities as compared to parent nucleosides containing 5-carbon ribose or deoxyribose sugar ring. In this review, we highlight the recent advances in synthesis and biological activities of nucleosides containing modified sugar rings reported between year Read More

Secondary metabolites containing oxazole, oxazoline and isoxazoline ring skeletons are widely distributed in both marine and terrestrial organisms. They possess significant biological activities such as anti-tumor, antibacterial, anti-viral, anti-malarial and immunosuppressive. The complexity in the molecular structures coupled with their wide biological properties, has attracted the attention of many synthetic and natural product Read More

A3 adenosine receptors (ARs) have long been viewed as potential therapeutic targets due to their association with a variety of pathophysiological processes. Development of potent and selective A3AR nucleoside ligands has been an area of interest of medicinal chemists since last two decades. Various prime modifications made on N6 and C-2 position of the adenosine moiety has led to the discovery of some of the mos Read More

Kainic acid and related members of kainoid family are amino acid-terpene hybrid natural products with three stereocenters and promising bioactivities. Kainoids have been isolated from diverse marine and terrestrial organisms and all of them feature a 3-carboxymethyl proline and C-4 side chain. The decorative molecular structure and intriguing biological profile of kainic acid inspired the synthetic chemists in engineeri Read More